Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen
Infertility is among the most serious medical problems worldwide. Male factors contribute to 40%–50% of all infertility cases, and approximately 7% of men worldwide are affected by infertility. Spermatozoa are extremely vulnerable to oxidative insult. Oxidative stress results in axonemal damage and...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-09-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/1557988320939731 |
| _version_ | 1811338079267454976 |
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| author | Wiktoria Kurkowska Agnieszka Bogacz Marta Janiszewska Ewa Gabryś Michał Tiszler Francesco Bellanti Sławomir Kasperczyk Anna Machoń-Grecka Michał Dobrakowski Aleksandra Kasperczyk |
| author_facet | Wiktoria Kurkowska Agnieszka Bogacz Marta Janiszewska Ewa Gabryś Michał Tiszler Francesco Bellanti Sławomir Kasperczyk Anna Machoń-Grecka Michał Dobrakowski Aleksandra Kasperczyk |
| author_sort | Wiktoria Kurkowska |
| collection | DOAJ |
| description | Infertility is among the most serious medical problems worldwide. Male factors contribute to 40%–50% of all infertility cases, and approximately 7% of men worldwide are affected by infertility. Spermatozoa are extremely vulnerable to oxidative insult. Oxidative stress results in axonemal damage and increased midpiece sperm morphological defects, which lead to reduced sperm motility. The aim of the study is to evaluate the association between sperm motility and the levels of selected antioxidants, cytokines, and markers of oxidative damage in the seminal plasma. The study group included 107 healthy males, who were split into two subgroups based on the percentage of motile spermatozoa after 1 hr: low motility (LM, n = 51) and high motility (HM, n = 56). The glucose-6-phosphate dehydrogenase (G6PD) activity was 52% lower in the LM group compared to that in the HM group. The level of malondialdehyde (MDA) was 12% higher in the LM group compared to that in the HM group. Similarly, the median values of interleukin (IL)-1β, IL-10, IL-12, and tumor necrosis factor alpha (TNF-α) were higher in the LM group than those in the HM group. Results of the present study revealed that the percentage of motile spermatozoa after 1 hr correlated positively with the levels of IL-1β, IL-10, IL-12, and TNFα. The lower motility of spermatozoa in healthy men is associated with a decreased activity of G6PD and increased levels of cytokines, which may be related to increased oxidative stress in seminal plasma that manifests as an increased level of MDA. |
| first_indexed | 2024-04-13T18:04:32Z |
| format | Article |
| id | doaj.art-6958f91e99a84e42b09432f12476c9ed |
| institution | Directory Open Access Journal |
| issn | 1557-9891 |
| language | English |
| last_indexed | 2024-04-13T18:04:32Z |
| publishDate | 2020-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj.art-6958f91e99a84e42b09432f12476c9ed2022-12-22T02:36:06ZengSAGE PublishingAmerican Journal of Men's Health1557-98912020-09-011410.1177/1557988320939731Oxidative Stress is Associated with Reduced Sperm Motility in Normal SemenWiktoria Kurkowska0Agnieszka Bogacz1Marta Janiszewska2Ewa Gabryś3Michał Tiszler4Francesco Bellanti5Sławomir Kasperczyk6Anna Machoń-Grecka7Michał Dobrakowski8Aleksandra Kasperczyk9Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze, PolandDepartment of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze, PolandDepartment of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze, PolandDepartment of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze, PolandDepartment of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze, PolandDepartment of Medical and Surgical Sciences, University of Foggia, Foggia, Puglia, ItalyDepartment of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze, PolandDepartment of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze, PolandDepartment of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze, PolandDepartment of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze, PolandInfertility is among the most serious medical problems worldwide. Male factors contribute to 40%–50% of all infertility cases, and approximately 7% of men worldwide are affected by infertility. Spermatozoa are extremely vulnerable to oxidative insult. Oxidative stress results in axonemal damage and increased midpiece sperm morphological defects, which lead to reduced sperm motility. The aim of the study is to evaluate the association between sperm motility and the levels of selected antioxidants, cytokines, and markers of oxidative damage in the seminal plasma. The study group included 107 healthy males, who were split into two subgroups based on the percentage of motile spermatozoa after 1 hr: low motility (LM, n = 51) and high motility (HM, n = 56). The glucose-6-phosphate dehydrogenase (G6PD) activity was 52% lower in the LM group compared to that in the HM group. The level of malondialdehyde (MDA) was 12% higher in the LM group compared to that in the HM group. Similarly, the median values of interleukin (IL)-1β, IL-10, IL-12, and tumor necrosis factor alpha (TNF-α) were higher in the LM group than those in the HM group. Results of the present study revealed that the percentage of motile spermatozoa after 1 hr correlated positively with the levels of IL-1β, IL-10, IL-12, and TNFα. The lower motility of spermatozoa in healthy men is associated with a decreased activity of G6PD and increased levels of cytokines, which may be related to increased oxidative stress in seminal plasma that manifests as an increased level of MDA.https://doi.org/10.1177/1557988320939731 |
| spellingShingle | Wiktoria Kurkowska Agnieszka Bogacz Marta Janiszewska Ewa Gabryś Michał Tiszler Francesco Bellanti Sławomir Kasperczyk Anna Machoń-Grecka Michał Dobrakowski Aleksandra Kasperczyk Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen American Journal of Men's Health |
| title | Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen |
| title_full | Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen |
| title_fullStr | Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen |
| title_full_unstemmed | Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen |
| title_short | Oxidative Stress is Associated with Reduced Sperm Motility in Normal Semen |
| title_sort | oxidative stress is associated with reduced sperm motility in normal semen |
| url | https://doi.org/10.1177/1557988320939731 |
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