Dynamics of humoral immunity during natural SARS-CoV-2 infection and/or after vaccination with the ‘Sputnik V’ vaccine
Comprehensive analysis of adaptive immune response to SARS-CoV-2 is critical for epidemiological monitoring, as well as for tracking immune response stages and vaccination strategies. Understanding the differences between immunity formed after COVID-19 infection and vaccine-induced immunity is a spe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2024-11-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/2919 |
| _version_ | 1826534011407695872 |
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| author | A. V. Ivanov M. A. Uvarova K. B. Frolov E. V. Semenova |
| author_facet | A. V. Ivanov M. A. Uvarova K. B. Frolov E. V. Semenova |
| author_sort | A. V. Ivanov |
| collection | DOAJ |
| description | Comprehensive analysis of adaptive immune response to SARS-CoV-2 is critical for epidemiological monitoring, as well as for tracking immune response stages and vaccination strategies. Understanding the differences between immunity formed after COVID-19 infection and vaccine-induced immunity is a specific task within this problem. Moreover, the obvious task is to assess the effect of repeated antigenic stimulation on immunological defense against SARS-CoV-2. The aim of present study was a comparative analysis of humoral immunity (anti-SARS-CoV-2 IgA and IgG) developing after natural infection with SARS-CoV-2 and/or after vaccination with anti-COVID vaccine “Sputnik V”. The study involved 36 volunteers. 21 of them had COVID-19 and were vaccinated 8-10 months later (group 1). In 15 primarily vaccinated persons, previous SARS-CoV-2 infection was excluded by means of regular PCR screening and serological testing (group 2). Results: Intensity of humoral immune response to the primary natural SARS-CoV-2 infection and similar indexes of antiviral adaptive immunity after vaccination with “Sputnik V” vaccine were similar in both groups. However, both maximal values of anti-SARS-CoV-2 IgA and IgG and the rates of post-vaccination humoral immune response differed significantly between the persons who have previously had COVID-19 and those who have not previously been infected with SARS-CoV-2. We’ve got statistically significant differences between two groups of participants using Student’s t test comparing the average maximum IgA levels after vaccination (p < 0.05). For IgG levels, these differences are less pronounced. In the first group, the average maximal values of specific IgA and IgG levels after natural infection with SARS-CoV-2 and after subsequent vaccination differed by more than 2 times. The time intervals for reaching maximal antibody levels after vaccination proved to be significantly shorter in the subjects who had a story of COVID-19, than in persons who did not report a clinical COVID-19 infection. Concerning the terms of arising IgG antibody response after vaccination versus cases of COVID-19 in the first group, we obtained a statistically significant difference by the Student’s t-test (p < 0.05). Hence, the persons with a previous natural COVID-19 infection develop a faster, stronger and more durable response to the “Sputnik V” vaccine than the subjects who had no such infection in their history |
| first_indexed | 2024-04-24T06:48:51Z |
| format | Article |
| id | doaj.art-695960fd8d6842b997dfb5312380895b |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:16:14Z |
| publishDate | 2024-11-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-695960fd8d6842b997dfb5312380895b2025-03-11T17:59:16ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2024-11-012661291130010.15789/1563-0625-DOH-29191863Dynamics of humoral immunity during natural SARS-CoV-2 infection and/or after vaccination with the ‘Sputnik V’ vaccineA. V. Ivanov0M. A. Uvarova1K. B. Frolov2E. V. Semenova3North-West Centre for Evidence-Based Medicine; N. Pirogov Clinic of Advanced Medical Technologies, St. Petersburg State University; St. Petersburg State Pediatric Medical UniversityNorth-West Centre for Evidence-Based MedicineSt. Petersburg State Pediatric Medical UniversityB. Konstantinov Institute of Nuclear Physics, NRC Kurchatov InstituteComprehensive analysis of adaptive immune response to SARS-CoV-2 is critical for epidemiological monitoring, as well as for tracking immune response stages and vaccination strategies. Understanding the differences between immunity formed after COVID-19 infection and vaccine-induced immunity is a specific task within this problem. Moreover, the obvious task is to assess the effect of repeated antigenic stimulation on immunological defense against SARS-CoV-2. The aim of present study was a comparative analysis of humoral immunity (anti-SARS-CoV-2 IgA and IgG) developing after natural infection with SARS-CoV-2 and/or after vaccination with anti-COVID vaccine “Sputnik V”. The study involved 36 volunteers. 21 of them had COVID-19 and were vaccinated 8-10 months later (group 1). In 15 primarily vaccinated persons, previous SARS-CoV-2 infection was excluded by means of regular PCR screening and serological testing (group 2). Results: Intensity of humoral immune response to the primary natural SARS-CoV-2 infection and similar indexes of antiviral adaptive immunity after vaccination with “Sputnik V” vaccine were similar in both groups. However, both maximal values of anti-SARS-CoV-2 IgA and IgG and the rates of post-vaccination humoral immune response differed significantly between the persons who have previously had COVID-19 and those who have not previously been infected with SARS-CoV-2. We’ve got statistically significant differences between two groups of participants using Student’s t test comparing the average maximum IgA levels after vaccination (p < 0.05). For IgG levels, these differences are less pronounced. In the first group, the average maximal values of specific IgA and IgG levels after natural infection with SARS-CoV-2 and after subsequent vaccination differed by more than 2 times. The time intervals for reaching maximal antibody levels after vaccination proved to be significantly shorter in the subjects who had a story of COVID-19, than in persons who did not report a clinical COVID-19 infection. Concerning the terms of arising IgG antibody response after vaccination versus cases of COVID-19 in the first group, we obtained a statistically significant difference by the Student’s t-test (p < 0.05). Hence, the persons with a previous natural COVID-19 infection develop a faster, stronger and more durable response to the “Sputnik V” vaccine than the subjects who had no such infection in their historyhttps://www.mimmun.ru/mimmun/article/view/2919sars-cov-2infectionvaccinesputnik vhumoral immunity |
| spellingShingle | A. V. Ivanov M. A. Uvarova K. B. Frolov E. V. Semenova Dynamics of humoral immunity during natural SARS-CoV-2 infection and/or after vaccination with the ‘Sputnik V’ vaccine Медицинская иммунология sars-cov-2 infection vaccine sputnik v humoral immunity |
| title | Dynamics of humoral immunity during natural SARS-CoV-2 infection and/or after vaccination with the ‘Sputnik V’ vaccine |
| title_full | Dynamics of humoral immunity during natural SARS-CoV-2 infection and/or after vaccination with the ‘Sputnik V’ vaccine |
| title_fullStr | Dynamics of humoral immunity during natural SARS-CoV-2 infection and/or after vaccination with the ‘Sputnik V’ vaccine |
| title_full_unstemmed | Dynamics of humoral immunity during natural SARS-CoV-2 infection and/or after vaccination with the ‘Sputnik V’ vaccine |
| title_short | Dynamics of humoral immunity during natural SARS-CoV-2 infection and/or after vaccination with the ‘Sputnik V’ vaccine |
| title_sort | dynamics of humoral immunity during natural sars cov 2 infection and or after vaccination with the sputnik v vaccine |
| topic | sars-cov-2 infection vaccine sputnik v humoral immunity |
| url | https://www.mimmun.ru/mimmun/article/view/2919 |
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