sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy
Background: Preeclampsia occurs more often in dichorionic than in monochorionic twin pregnancy. We hypothesize that serum concentrations of biomarkers: placental growth factor (PlGF), serum soluble fms-like tyrosine kinase-1 (sFlt-1), and endoglin (Eng) differ between monochorionic and dichorionic t...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/7/1181 |
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| author | Szymon Kozłowski Anna Stelmaszczyk-Emmel Iwona Szymusik Aleksandra Saletra-Bielińska Robert Brawura-Biskupski-Samaha Paweł Pietruski Agnieszka Osińska Katarzyna Kosińska-Kaczyńska |
| author_facet | Szymon Kozłowski Anna Stelmaszczyk-Emmel Iwona Szymusik Aleksandra Saletra-Bielińska Robert Brawura-Biskupski-Samaha Paweł Pietruski Agnieszka Osińska Katarzyna Kosińska-Kaczyńska |
| author_sort | Szymon Kozłowski |
| collection | DOAJ |
| description | Background: Preeclampsia occurs more often in dichorionic than in monochorionic twin pregnancy. We hypothesize that serum concentrations of biomarkers: placental growth factor (PlGF), serum soluble fms-like tyrosine kinase-1 (sFlt-1), and endoglin (Eng) differ between monochorionic and dichorionic twin pregnancies. Methods: A prospective observational study including 43 monochorionic and 36 dichorionic twin gestation was conducted. Blood samples were collected twice from all participants: between 11 + 0 and 13 + 6 and between 32 + 0 and 34 + 0 weeks of gestation. PlGF, sFlt-1 and Eng were measured using immnunoenzymatic assays. Results: We found a significantly higher concentration of sFlt-1 in dichorionic in comparison to monochorionic pregnancies in both the first and third trimesters. PlGF and sEng levels did not differ between mono- and dichorionic gestation in both study periods. sFlt-1 level was related to twin gestation chorionicity, while PlGF expression was not. PlGF, sFlt-1 and sEng concentrations increased significantly during gestation and were much higher in the third trimester compared to the values measured in the first trimester. Conclusions: Angiogenic biomarkers expression differ between dichorionic and monochorionic twin pregnancy. The sFlt-1 level is related to chorionicity of a twin gestation. |
| first_indexed | 2024-03-10T09:57:46Z |
| format | Article |
| id | doaj.art-695a289e84774d0da64f3d5e81e527cf |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T09:57:46Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-695a289e84774d0da64f3d5e81e527cf2023-11-22T02:13:22ZengMDPI AGDiagnostics2075-44182021-06-01117118110.3390/diagnostics11071181sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of PregnancySzymon Kozłowski0Anna Stelmaszczyk-Emmel1Iwona Szymusik2Aleksandra Saletra-Bielińska3Robert Brawura-Biskupski-Samaha4Paweł Pietruski5Agnieszka Osińska6Katarzyna Kosińska-Kaczyńska7University Center for Woman and Newborn Health of the Medical University of Warsaw, Starynkiewicza Square 1/3, 02-015 Warsaw, PolandDepartment of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Żwirki i Wigury 63A, 02-091 Warsaw, Poland1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Square 1/3, 02-015 Warsaw, Poland1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Square 1/3, 02-015 Warsaw, Poland1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Square 1/3, 02-015 Warsaw, PolandIndependent Public Complex of Healthcare Institutions in Pułtusk, 3 Maja 5, 06-100 Pułtusk, Poland2nd Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, Cegłowska 80, 01-809 Warsaw, Poland2nd Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, Cegłowska 80, 01-809 Warsaw, PolandBackground: Preeclampsia occurs more often in dichorionic than in monochorionic twin pregnancy. We hypothesize that serum concentrations of biomarkers: placental growth factor (PlGF), serum soluble fms-like tyrosine kinase-1 (sFlt-1), and endoglin (Eng) differ between monochorionic and dichorionic twin pregnancies. Methods: A prospective observational study including 43 monochorionic and 36 dichorionic twin gestation was conducted. Blood samples were collected twice from all participants: between 11 + 0 and 13 + 6 and between 32 + 0 and 34 + 0 weeks of gestation. PlGF, sFlt-1 and Eng were measured using immnunoenzymatic assays. Results: We found a significantly higher concentration of sFlt-1 in dichorionic in comparison to monochorionic pregnancies in both the first and third trimesters. PlGF and sEng levels did not differ between mono- and dichorionic gestation in both study periods. sFlt-1 level was related to twin gestation chorionicity, while PlGF expression was not. PlGF, sFlt-1 and sEng concentrations increased significantly during gestation and were much higher in the third trimester compared to the values measured in the first trimester. Conclusions: Angiogenic biomarkers expression differ between dichorionic and monochorionic twin pregnancy. The sFlt-1 level is related to chorionicity of a twin gestation.https://www.mdpi.com/2075-4418/11/7/1181twin pregnancyPlGFsFlt-1sEngpreeclampsiachorionicity |
| spellingShingle | Szymon Kozłowski Anna Stelmaszczyk-Emmel Iwona Szymusik Aleksandra Saletra-Bielińska Robert Brawura-Biskupski-Samaha Paweł Pietruski Agnieszka Osińska Katarzyna Kosińska-Kaczyńska sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy Diagnostics twin pregnancy PlGF sFlt-1 sEng preeclampsia chorionicity |
| title | sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy |
| title_full | sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy |
| title_fullStr | sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy |
| title_full_unstemmed | sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy |
| title_short | sFlt-1, Not PlGF, Is Related to Twin Gestation Choronicity in the First and Third Trimesters of Pregnancy |
| title_sort | sflt 1 not plgf is related to twin gestation choronicity in the first and third trimesters of pregnancy |
| topic | twin pregnancy PlGF sFlt-1 sEng preeclampsia chorionicity |
| url | https://www.mdpi.com/2075-4418/11/7/1181 |
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