Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues
Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-unsaturated γ-lactone. While many studies have addre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/14/9/3621/ |
| _version_ | 1818210608652222464 |
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| author | Naoto Kojima Tetsuaki Tanaka |
| author_facet | Naoto Kojima Tetsuaki Tanaka |
| author_sort | Naoto Kojima |
| collection | DOAJ |
| description | Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-unsaturated γ-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues. |
| first_indexed | 2024-12-12T05:19:19Z |
| format | Article |
| id | doaj.art-695a3c2591654aa582c2172a13d409f5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T05:19:19Z |
| publishDate | 2009-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-695a3c2591654aa582c2172a13d409f52022-12-22T00:36:40ZengMDPI AGMolecules1420-30492009-09-011493621366110.3390/molecules14093621Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel AnaloguesNaoto KojimaTetsuaki TanakaMost Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-unsaturated γ-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues.http://www.mdpi.com/1420-3049/14/9/3621/Annonaceous acetogeninsantitumor activityanaloguesstructure–activity relationshippolyketides |
| spellingShingle | Naoto Kojima Tetsuaki Tanaka Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues Molecules Annonaceous acetogenins antitumor activity analogues structure–activity relationship polyketides |
| title | Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues |
| title_full | Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues |
| title_fullStr | Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues |
| title_full_unstemmed | Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues |
| title_short | Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues |
| title_sort | medicinal chemistry of annonaceous acetogenins design synthesis and biological evaluation of novel analogues |
| topic | Annonaceous acetogenins antitumor activity analogues structure–activity relationship polyketides |
| url | http://www.mdpi.com/1420-3049/14/9/3621/ |
| work_keys_str_mv | AT naotokojima medicinalchemistryofannonaceousacetogeninsdesignsynthesisandbiologicalevaluationofnovelanalogues AT tetsuakitanaka medicinalchemistryofannonaceousacetogeninsdesignsynthesisandbiologicalevaluationofnovelanalogues |