TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance
Telomerase protects chromosome ends in stem cells and cancer cells. Here the authors show that Trimethylguaonsine Synthase 1 (TGS-1) – dependent trimethylguanosine capping of the RNA component of the human telomerase complex has an important role in directing telomere dependent telomere maintenance...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29907-z |
| _version_ | 1811338810324156416 |
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| author | Valentina Buemi Odessa Schillaci Mariangela Santorsola Deborah Bonazza Pamela Veneziano Broccia Annie Zappone Cristina Bottin Giulia Dell’Omo Sylvie Kengne Stefano Cacchione Grazia Daniela Raffa Silvano Piazza Fabrizio d’Adda di Fagagna Roberta Benetti Maurizio Cortale Fabrizio Zanconati Giannino Del Sal Stefan Schoeftner |
| author_facet | Valentina Buemi Odessa Schillaci Mariangela Santorsola Deborah Bonazza Pamela Veneziano Broccia Annie Zappone Cristina Bottin Giulia Dell’Omo Sylvie Kengne Stefano Cacchione Grazia Daniela Raffa Silvano Piazza Fabrizio d’Adda di Fagagna Roberta Benetti Maurizio Cortale Fabrizio Zanconati Giannino Del Sal Stefan Schoeftner |
| author_sort | Valentina Buemi |
| collection | DOAJ |
| description | Telomerase protects chromosome ends in stem cells and cancer cells. Here the authors show that Trimethylguaonsine Synthase 1 (TGS-1) – dependent trimethylguanosine capping of the RNA component of the human telomerase complex has an important role in directing telomere dependent telomere maintenance and suppressing the ALT pathway in cancer cells. |
| first_indexed | 2024-04-13T18:17:02Z |
| format | Article |
| id | doaj.art-695aa97a2df5484da202dfc53c1f242a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T18:17:02Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-695aa97a2df5484da202dfc53c1f242a2022-12-22T02:35:39ZengNature PortfolioNature Communications2041-17232022-04-0113111510.1038/s41467-022-29907-zTGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenanceValentina Buemi0Odessa Schillaci1Mariangela Santorsola2Deborah Bonazza3Pamela Veneziano Broccia4Annie Zappone5Cristina Bottin6Giulia Dell’Omo7Sylvie Kengne8Stefano Cacchione9Grazia Daniela Raffa10Silvano Piazza11Fabrizio d’Adda di Fagagna12Roberta Benetti13Maurizio Cortale14Fabrizio Zanconati15Giannino Del Sal16Stefan Schoeftner17Dipartimento di Scienze della Vita, Università degli Studi di TriesteDipartimento di Scienze della Vita, Università degli Studi di TriesteDipartimento di Scienze della Vita, Università degli Studi di TriesteStruttura Complessa di Anatomia ed Istologia Patologica, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) TriesteDipartimento di Scienze della Vita, Università degli Studi di TriesteDipartimento di Scienze della Vita, Università degli Studi di TriesteDipartimento Universitario Clinico di Scienze Mediche Chirurgiche e della Salute, Università degli Studi di TriesteIFOM Foundation-FIRC Institute of Molecular Oncology FoundationDipartimento di Scienze della Vita, Università degli Studi di TriesteDipartimento di Biologia e Biotecnologie, Sapienza Università di RomaDipartimento di Biologia e Biotecnologie, Sapienza Università di RomaInternational Centre for Genetic Engineering and Biotechnology (ICGEB)IFOM Foundation-FIRC Institute of Molecular Oncology FoundationDipartimento di Area Medica (Dame), Università degli Studi di UdineStruttura Complessa di Chirurgia Toracica, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) TriesteStruttura Complessa di Anatomia ed Istologia Patologica, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI) TriesteDipartimento di Scienze della Vita, Università degli Studi di TriesteDipartimento di Scienze della Vita, Università degli Studi di TriesteTelomerase protects chromosome ends in stem cells and cancer cells. Here the authors show that Trimethylguaonsine Synthase 1 (TGS-1) – dependent trimethylguanosine capping of the RNA component of the human telomerase complex has an important role in directing telomere dependent telomere maintenance and suppressing the ALT pathway in cancer cells.https://doi.org/10.1038/s41467-022-29907-z |
| spellingShingle | Valentina Buemi Odessa Schillaci Mariangela Santorsola Deborah Bonazza Pamela Veneziano Broccia Annie Zappone Cristina Bottin Giulia Dell’Omo Sylvie Kengne Stefano Cacchione Grazia Daniela Raffa Silvano Piazza Fabrizio d’Adda di Fagagna Roberta Benetti Maurizio Cortale Fabrizio Zanconati Giannino Del Sal Stefan Schoeftner TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance Nature Communications |
| title | TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance |
| title_full | TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance |
| title_fullStr | TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance |
| title_full_unstemmed | TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance |
| title_short | TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance |
| title_sort | tgs1 mediates 2 2 7 trimethyl guanosine capping of the human telomerase rna to direct telomerase dependent telomere maintenance |
| url | https://doi.org/10.1038/s41467-022-29907-z |
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