Vitamin A depletion alters sensitivity of motor behavior to MK-801 in C57BL/6J mice
<p>Abstract</p> <p>Background</p> <p>Vitamin A and its derivatives (retinoids) are crucial for the development, maintenance and morphogenesis of the central nervous system (CNS). Although motor impairment has been reported in postnatal vitamin A depletion rodents, the e...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-01-01
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| Series: | Behavioral and Brain Functions |
| Online Access: | http://www.behavioralandbrainfunctions.com/content/6/1/7 |
| _version_ | 1811286929888509952 |
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| author | Zhu Hui Li Xingwang Zhang Zhao Zou Hong Shi Junwei Ji Baohu Zhang Ming Feng Guoyin Jin Meilei Yu Lei He Lin Wan Chunling |
| author_facet | Zhu Hui Li Xingwang Zhang Zhao Zou Hong Shi Junwei Ji Baohu Zhang Ming Feng Guoyin Jin Meilei Yu Lei He Lin Wan Chunling |
| author_sort | Zhu Hui |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Vitamin A and its derivatives (retinoids) are crucial for the development, maintenance and morphogenesis of the central nervous system (CNS). Although motor impairment has been reported in postnatal vitamin A depletion rodents, the effect of vitamin A depletion on homeostasis maintaining capability in response to external interference is not clear.</p> <p>Methods</p> <p>In the current study, we measured the effect of vitamin A depletion on motor ability and pain sensitivity under two different conditions: 1. prior to any injection and 2. after the injection of an N-methyl-D-aspartate (NMDA) receptor antagonist (MK-801).</p> <p>Results</p> <p>Vitamin A depletion mice showed decreased body weight, enhanced locomotor activity, increased rearing and less tail flick latency. Vitamin A depletion also induced hypersensitivity of stereotypy, ataxia, rearing, and tail flick latency to MK-801, but hyposensitivity of locomotion to MK-801.</p> <p>Conclusions</p> <p>These findings suggest that vitamin A depletion affect broad basal behavior and disrupt homeostasis maintaining capability in response to glutamate perturbation. We provide a useful animal model for assessing the role of vitamin A depletion in regulating animal behavior, and for detecting how neurotransmitter pathways might be involved in vitamin A depletion related behavioral abnormalities.</p> |
| first_indexed | 2024-04-13T03:09:45Z |
| format | Article |
| id | doaj.art-695adec10ee949b893b30e3c7613a8df |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-04-13T03:09:45Z |
| publishDate | 2010-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-695adec10ee949b893b30e3c7613a8df2022-12-22T03:05:07ZengBMCBehavioral and Brain Functions1744-90812010-01-0161710.1186/1744-9081-6-7Vitamin A depletion alters sensitivity of motor behavior to MK-801 in C57BL/6J miceZhu HuiLi XingwangZhang ZhaoZou HongShi JunweiJi BaohuZhang MingFeng GuoyinJin MeileiYu LeiHe LinWan Chunling<p>Abstract</p> <p>Background</p> <p>Vitamin A and its derivatives (retinoids) are crucial for the development, maintenance and morphogenesis of the central nervous system (CNS). Although motor impairment has been reported in postnatal vitamin A depletion rodents, the effect of vitamin A depletion on homeostasis maintaining capability in response to external interference is not clear.</p> <p>Methods</p> <p>In the current study, we measured the effect of vitamin A depletion on motor ability and pain sensitivity under two different conditions: 1. prior to any injection and 2. after the injection of an N-methyl-D-aspartate (NMDA) receptor antagonist (MK-801).</p> <p>Results</p> <p>Vitamin A depletion mice showed decreased body weight, enhanced locomotor activity, increased rearing and less tail flick latency. Vitamin A depletion also induced hypersensitivity of stereotypy, ataxia, rearing, and tail flick latency to MK-801, but hyposensitivity of locomotion to MK-801.</p> <p>Conclusions</p> <p>These findings suggest that vitamin A depletion affect broad basal behavior and disrupt homeostasis maintaining capability in response to glutamate perturbation. We provide a useful animal model for assessing the role of vitamin A depletion in regulating animal behavior, and for detecting how neurotransmitter pathways might be involved in vitamin A depletion related behavioral abnormalities.</p>http://www.behavioralandbrainfunctions.com/content/6/1/7 |
| spellingShingle | Zhu Hui Li Xingwang Zhang Zhao Zou Hong Shi Junwei Ji Baohu Zhang Ming Feng Guoyin Jin Meilei Yu Lei He Lin Wan Chunling Vitamin A depletion alters sensitivity of motor behavior to MK-801 in C57BL/6J mice Behavioral and Brain Functions |
| title | Vitamin A depletion alters sensitivity of motor behavior to MK-801 in C57BL/6J mice |
| title_full | Vitamin A depletion alters sensitivity of motor behavior to MK-801 in C57BL/6J mice |
| title_fullStr | Vitamin A depletion alters sensitivity of motor behavior to MK-801 in C57BL/6J mice |
| title_full_unstemmed | Vitamin A depletion alters sensitivity of motor behavior to MK-801 in C57BL/6J mice |
| title_short | Vitamin A depletion alters sensitivity of motor behavior to MK-801 in C57BL/6J mice |
| title_sort | vitamin a depletion alters sensitivity of motor behavior to mk 801 in c57bl 6j mice |
| url | http://www.behavioralandbrainfunctions.com/content/6/1/7 |
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