Lineage tracing of T cell differentiation from T-iPSC by 2D feeder-free culture and 3D organoid culture

Lineage tracing of T cell differentiation from T-iPSC by 2D feeder-free culture and 3D organoid culture

IntroductionT cells induced from induced pluripotent stem cells(iPSCs) derived from antigen-specific T cells (T-iPS-T cells) are an attractive tool for T cell immunotherapy. The induction of cytotoxic T-iPS-T cells is well established in feeder-free condition for the aim of off-the-shelf production,...

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Bibliographic Details
Main Authors: Yoshitaka Ishiguro, Shoichi Iriguchi, Shinya Asano, Tokuyuki Shinohara, Sara Shiina, Suguru Arima, Yoshiaki Kassai, Yoshiharu Sakai, Kazutaka Obama, Shin Kaneko
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
iPSC
T cell differentiation
CD4
3D organoid
scRNA seq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1303713/full

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