Emerging roles of Aurora-A kinase in cancer therapy resistance

Emerging roles of Aurora-A kinase in cancer therapy resistance

Aurora kinase A (Aurora-A), a serine/threonine kinase, plays a pivotal role in various cellular processes, including mitotic entry, centrosome maturation and spindle formation. Overexpression or gene-amplification/mutation of Aurora-A kinase occurs in different types of cancer, including lung cancer...

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Bibliographic Details
Main Authors: Dayong Zheng, Jun Li, Han Yan, Gang Zhang, Wei Li, Edward Chu, Ning Wei
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Aurora-A
Therapy resistance
Chemoresistance
Targeted therapy
Radioresistance
Synthetic lethality
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523001028

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http://www.sciencedirect.com/science/article/pii/S2211383523001028

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