THE EFFECT OF DIFFERENT DOSES OF COORDINATION COMPOUNDS OF GERMANIUM WITH NICOTINIC ACID ON LIPID PEROXIDATION AND COMPARATIVE INFLUENCE OF COORDINATION COMPOUNDS OF GERMANIUM WITH DIFFERENT BIOLIGANDS ON FATTY ACID SPECTRUM OF LIPIDS OF CARDIOMYOCYTES IN
According to the State Statistics Service, circulatory system diseases and malignant neoplasms take the first and second places among the causes of mortality in Ukraine. It is generally known that the basic chemotherapy principle is inhibition of mitotic and metabolic processes of cancer cells, whil...
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| Format: | Article |
| Language: | English |
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Bogomolets National Medical University
2016-04-01
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| Series: | Ukrainian Scientific Medical Youth Journal |
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| Online Access: | https://mmj.nmuofficial.com/index.php/journal/article/view/141 |
| Summary: | According to the State Statistics Service, circulatory system diseases and malignant neoplasms take the first and second places among the causes of mortality in Ukraine. It is generally known that the basic chemotherapy principle is inhibition of mitotic and metabolic processes of cancer cells, while normal tissues are also sensitive to the action of chemotherapeutic agents, which often leads to the development of adverse effects: cardiovascular disorders (heart failure, arrhythmia, tachycardia hypotension), bone marrow suppression etc.
One of the mechanisms of anthracycline antibiotics cytotoxicity is the enhanced production of free radicals and the increased oxidative stress.
The aim of the study was to investigate the effect of different doses of the new coordination complex compound of germanium with nicotinic acid (MIGU-1) on the process of lipid peroxidation in rat’s myocardium and to compare the impact of new germanium compounds with different bioligands (MIGU-1, OE-5 and OK-1) on the fatty acid spectrum of rat’s cardiomyocyte lipids in experimental chronic doxorubicin-induced intoxication.
Based on the results of our experimental studies we found that MIGU-1 10 mg/kg i.p. once daily had the optimal pharmacological effect in the correction of the oxidative stress manifestations in the rat’s myocardium, and MIGU-1 and OE-5 compounds improved the fatty acid spectrum of cardiomyocytes lipids in chronic doxorubicin-induced intoxication proving the relevance and feasibility of the investigation of their mechanisms of action as potential cardioprotectors. |
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| ISSN: | 2786-6661 2786-667X |