Efficient differentiation of human primordial germ cells through geometric control reveals a key role for Nodal signaling

Efficient differentiation of human primordial germ cells through geometric control reveals a key role for Nodal signaling

Human primordial germ cells (hPGCs) form around the time of implantation and are the precursors of eggs and sperm. Many aspects of hPGC specification remain poorly understood because of the inaccessibility of the early postimplantation human embryo for study. Here, we show that micropatterned human...

Full description

Bibliographic Details
Main Authors: Kyoung Jo, Seth Teague, Bohan Chen, Hina Aftab Khan, Emily Freeburne, Hunter Li, Bolin Li, Ran Ran, Jason R Spence, Idse Heemskerk
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
human pluripotent stem cells
cell fate patterning
primordial germ cells
cell signaling
micropatterning
Online Access:https://elifesciences.org/articles/72811

Similar Items

Similar Items