A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration
Background: Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive disease with a poor prognosis for advanced tumors. Anoikis play a key role in cancer metastasis, facilitating the detachment and survival of cancer cells from the primary tumor site. However, few studies have focused on...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.984273/full |
| _version_ | 1818495915441258496 |
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| author | Hao Chi Puyu Jiang Ke Xu Yue Zhao Yue Zhao Bingyu Song Gaoge Peng Bingsheng He Xin Liu Zhijia Xia Gang Tian |
| author_facet | Hao Chi Puyu Jiang Ke Xu Yue Zhao Yue Zhao Bingyu Song Gaoge Peng Bingsheng He Xin Liu Zhijia Xia Gang Tian |
| author_sort | Hao Chi |
| collection | DOAJ |
| description | Background: Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive disease with a poor prognosis for advanced tumors. Anoikis play a key role in cancer metastasis, facilitating the detachment and survival of cancer cells from the primary tumor site. However, few studies have focused on the role of anoikis in HNSC, especially on the prognosis.Methods: Anoikis-related genes (ANRGs) integrated from Genecards and Harmonizome portals were used to identify HNSCC subtypes and to construct a prognostic model for HNSCC patients. Also, we explored the immune microenvironment and enrichment pathways between different subtypes. Finally, we provide clinical experts with a novel nomogram based on ANRGs, with DCA curves indicating the potential clinical benefit of the model for clinical strategies.Results: We identified 69 survival-related HNSCC anoikis-related DEGs, from which 7 genes were selected to construct prognostic models. The prognostic risk score was identified as an independent prognostic factor. Functional analysis showed that these high and low risk groups had different immune status and drug sensitivity. Next risk scores were combined with HNSCC clinicopathological features together to construct a nomogram, and DCA analysis showed that the model could benefit patients from clinical treatment strategies.Conclusion: The predictive seven-gene signature and nomogram established in this study can assist clinicians in selecting personalized treatment for patients with HNSCC. |
| first_indexed | 2024-12-10T18:26:49Z |
| format | Article |
| id | doaj.art-6961e0103b4b42dd9a8fca9d2fd678b8 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-10T18:26:49Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-6961e0103b4b42dd9a8fca9d2fd678b82022-12-22T01:38:04ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-08-011310.3389/fgene.2022.984273984273A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltrationHao Chi0Puyu Jiang1Ke Xu2Yue Zhao3Yue Zhao4Bingyu Song5Gaoge Peng6Bingsheng He7Xin Liu8Zhijia Xia9Gang Tian10Clinical Medical College, Southwest Medical University, Luzhou, ChinaDepartment of Otorhinolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Oncology, Chongqing General Hospital, Chongqing, ChinaDepartment of Breast Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, ChinaDepartment of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, GermanyDepartment of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaClinical Medical College, Southwest Medical University, Luzhou, ChinaDepartment of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, GermanyDepartment of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, ChinaBackground: Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive disease with a poor prognosis for advanced tumors. Anoikis play a key role in cancer metastasis, facilitating the detachment and survival of cancer cells from the primary tumor site. However, few studies have focused on the role of anoikis in HNSC, especially on the prognosis.Methods: Anoikis-related genes (ANRGs) integrated from Genecards and Harmonizome portals were used to identify HNSCC subtypes and to construct a prognostic model for HNSCC patients. Also, we explored the immune microenvironment and enrichment pathways between different subtypes. Finally, we provide clinical experts with a novel nomogram based on ANRGs, with DCA curves indicating the potential clinical benefit of the model for clinical strategies.Results: We identified 69 survival-related HNSCC anoikis-related DEGs, from which 7 genes were selected to construct prognostic models. The prognostic risk score was identified as an independent prognostic factor. Functional analysis showed that these high and low risk groups had different immune status and drug sensitivity. Next risk scores were combined with HNSCC clinicopathological features together to construct a nomogram, and DCA analysis showed that the model could benefit patients from clinical treatment strategies.Conclusion: The predictive seven-gene signature and nomogram established in this study can assist clinicians in selecting personalized treatment for patients with HNSCC.https://www.frontiersin.org/articles/10.3389/fgene.2022.984273/fullanoikismodelbioinformaticsprognosisHNSCC |
| spellingShingle | Hao Chi Puyu Jiang Ke Xu Yue Zhao Yue Zhao Bingyu Song Gaoge Peng Bingsheng He Xin Liu Zhijia Xia Gang Tian A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration Frontiers in Genetics anoikis model bioinformatics prognosis HNSCC |
| title | A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration |
| title_full | A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration |
| title_fullStr | A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration |
| title_full_unstemmed | A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration |
| title_short | A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration |
| title_sort | novel anoikis related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration |
| topic | anoikis model bioinformatics prognosis HNSCC |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.984273/full |
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