The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.

Newborns and young infants are at higher risk for infections than adults, and manifest suboptimal vaccine responses, motivating a search for novel immunomodulators and/or vaccine adjuvants effective in early life. In contrast to most TLR agonists (TLRA), TLR8 agonists such as imidazoquinolines (IMQs...

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Main Authors: Lakshmi Ganapathi, Simon Van Haren, David J Dowling, Ilana Bergelson, Nikunj M Shukla, Subbalakshmi S Malladi, Rajalakshmi Balakrishna, Hiromi Tanji, Umeharu Ohto, Toshiyuki Shimizu, Sunil A David, Ofer Levy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4537157?pdf=render

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