Translational regulation of cell invasion through extracellular matrix—an emerging role for ribosomes [version 1; peer review: 1 approved, 2 approved with reservations]

Many developmental and physiological processes require cells to invade and migrate through extracellular matrix barriers. This specialized cellular behavior is also misregulated in many diseases, such as immune disorders and cancer. Cell invasive activity is driven by pro-invasive transcriptional ne...

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Main Authors: Isabel W. Kenny-Ganzert, Siddharthan Balachandar Thendral, David R. Sherwood
Format: Article
Language:English
Published: F1000 Research Ltd 2023-11-01
Series:F1000Research
Subjects:
Online Access:https://f1000research.com/articles/12-1528/v1
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author Isabel W. Kenny-Ganzert
Siddharthan Balachandar Thendral
David R. Sherwood
author_facet Isabel W. Kenny-Ganzert
Siddharthan Balachandar Thendral
David R. Sherwood
author_sort Isabel W. Kenny-Ganzert
collection DOAJ
description Many developmental and physiological processes require cells to invade and migrate through extracellular matrix barriers. This specialized cellular behavior is also misregulated in many diseases, such as immune disorders and cancer. Cell invasive activity is driven by pro-invasive transcriptional networks that activate the expression of genes encoding numerous different proteins that expand and regulate the cytoskeleton, endomembrane system, cell adhesion, signaling pathways, and metabolic networks. While detailed mechanistic studies have uncovered crucial insights into pro-invasive transcriptional networks and the distinct cell biological attributes of invasive cells, less is known about how invasive cells modulate mRNA translation to meet the robust, dynamic, and unique protein production needs of cell invasion. In this review we outline known modes of translation regulation promoting cell invasion and focus on recent studies revealing elegant mechanisms that expand ribosome biogenesis within invasive cells to meet the increased protein production requirements to invade and migrate through extracellular matrix barriers.
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spelling doaj.art-69641ea8832a4c57939744c4f523230c2024-04-16T00:00:01ZengF1000 Research LtdF1000Research2046-14022023-11-0112157192Translational regulation of cell invasion through extracellular matrix—an emerging role for ribosomes [version 1; peer review: 1 approved, 2 approved with reservations]Isabel W. Kenny-Ganzert0Siddharthan Balachandar Thendral1David R. Sherwood2https://orcid.org/0000-0002-4448-6917Biology, Duke University, Durham, North Carolina, 27708, USABiology, Duke University, Durham, North Carolina, 27708, USABiology, Duke University, Durham, North Carolina, 27708, USAMany developmental and physiological processes require cells to invade and migrate through extracellular matrix barriers. This specialized cellular behavior is also misregulated in many diseases, such as immune disorders and cancer. Cell invasive activity is driven by pro-invasive transcriptional networks that activate the expression of genes encoding numerous different proteins that expand and regulate the cytoskeleton, endomembrane system, cell adhesion, signaling pathways, and metabolic networks. While detailed mechanistic studies have uncovered crucial insights into pro-invasive transcriptional networks and the distinct cell biological attributes of invasive cells, less is known about how invasive cells modulate mRNA translation to meet the robust, dynamic, and unique protein production needs of cell invasion. In this review we outline known modes of translation regulation promoting cell invasion and focus on recent studies revealing elegant mechanisms that expand ribosome biogenesis within invasive cells to meet the increased protein production requirements to invade and migrate through extracellular matrix barriers.https://f1000research.com/articles/12-1528/v1cell invasion cell migration translational regulation translation initiation ribosomes ribosome biogenesiseng
spellingShingle Isabel W. Kenny-Ganzert
Siddharthan Balachandar Thendral
David R. Sherwood
Translational regulation of cell invasion through extracellular matrix—an emerging role for ribosomes [version 1; peer review: 1 approved, 2 approved with reservations]
F1000Research
cell invasion
cell migration
translational regulation
translation initiation
ribosomes
ribosome biogenesis
eng
title Translational regulation of cell invasion through extracellular matrix—an emerging role for ribosomes [version 1; peer review: 1 approved, 2 approved with reservations]
title_full Translational regulation of cell invasion through extracellular matrix—an emerging role for ribosomes [version 1; peer review: 1 approved, 2 approved with reservations]
title_fullStr Translational regulation of cell invasion through extracellular matrix—an emerging role for ribosomes [version 1; peer review: 1 approved, 2 approved with reservations]
title_full_unstemmed Translational regulation of cell invasion through extracellular matrix—an emerging role for ribosomes [version 1; peer review: 1 approved, 2 approved with reservations]
title_short Translational regulation of cell invasion through extracellular matrix—an emerging role for ribosomes [version 1; peer review: 1 approved, 2 approved with reservations]
title_sort translational regulation of cell invasion through extracellular matrix an emerging role for ribosomes version 1 peer review 1 approved 2 approved with reservations
topic cell invasion
cell migration
translational regulation
translation initiation
ribosomes
ribosome biogenesis
eng
url https://f1000research.com/articles/12-1528/v1
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AT siddharthanbalachandarthendral translationalregulationofcellinvasionthroughextracellularmatrixanemergingroleforribosomesversion1peerreview1approved2approvedwithreservations
AT davidrsherwood translationalregulationofcellinvasionthroughextracellularmatrixanemergingroleforribosomesversion1peerreview1approved2approvedwithreservations