Joint analyses of human milk fatty acids, phospholipids, and choline in association with cognition and temperament traits during the first 6 months of life
Early dietary exposure via human milk nutrients offers a window of opportunity to support cognitive and temperament development. While several studies have focused on associations of few pre-selected human milk nutrients with cognition and temperament, it is highly plausible that human milk nutrient...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.919769/full |
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| author | Tengfei Li Tengfei Li Tinu M. Samuel Ziliang Zhu Brittany Howell Seoyoon Cho Kristine Baluyot Heather Hazlett Jed T. Elison Di Wu Jonas Hauser Norbert Sprenger Hongtu Zhu Hongtu Zhu Weili Lin Weili Lin |
| author_facet | Tengfei Li Tengfei Li Tinu M. Samuel Ziliang Zhu Brittany Howell Seoyoon Cho Kristine Baluyot Heather Hazlett Jed T. Elison Di Wu Jonas Hauser Norbert Sprenger Hongtu Zhu Hongtu Zhu Weili Lin Weili Lin |
| author_sort | Tengfei Li |
| collection | DOAJ |
| description | Early dietary exposure via human milk nutrients offers a window of opportunity to support cognitive and temperament development. While several studies have focused on associations of few pre-selected human milk nutrients with cognition and temperament, it is highly plausible that human milk nutrients synergistically and jointly support cognitive and behavioral development in early life. We aimed to discern the combined associations of three major classes of human milk nutrients with cognition and temperament during the first 6 months of life when human milk is the primary source of an infant’s nutrition and explore whether there were persistent effects up to 18 months old. The Mullen Scales of Early Learning and Infant Behavior Questionnaires—Revised were used to assess cognition and temperament, respectively, of 54 exclusively/predominantly breastfed infants in the first 6 months of life, whose follow-ups were conducted at 6–9, 9–12, and 12–18 months old. Human milk samples were obtained from the mothers of the participants at less than 6 months of age and analyzed for fatty acids [total monounsaturated fatty acids, polyunsaturated fatty acid, total saturated fatty acid (TSFA), arachidonic acid (ARA), docosahexaenoic acid (DHA), ARA/DHA, omega-6/omega-3 polyunsaturated fatty acids ratio (n-6/n-3)], phospholipids [phosphatidylcholine, phosphatidylethanolamine (PE), phosphatidylinositol (PI), sphingomyelin], and choline [free choline, phosphocholine (PCho), glycerophosphocholine]. Feature selection was performed to select nutrients associated with cognition and temperament. The combined effects of selected nutrients were analyzed using multiple regression. A positive association between the arachidonic acid (ARA) and surgency was observed (p = 0.024). A significant effect of DHA, n-6/n-3, PE, and TSFA concentrations on receptive language (R2 = 0.39, p = 0.025) and the elevated ARA, PCho, and PI with increased surgency (R2 = 0.43, p = 0.003) was identified, suggesting that DHA and ARA may have distinct roles for temperament and language functions. Furthermore, the exploratory association analyses suggest that the effects of human milk nutrients on R.L. and surgency may persist beyond the first 6 months of life, particularly surgency at 12–18 months (p = 0.002). Our study highlighted that various human milk nutrients work together to support the development of cognition and temperament traits during early infancy. |
| first_indexed | 2024-12-10T18:27:35Z |
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| id | doaj.art-696531212319489b8830886b36e1da85 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-10T18:27:35Z |
| publishDate | 2022-08-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-696531212319489b8830886b36e1da852022-12-22T01:38:02ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-08-01910.3389/fnut.2022.919769919769Joint analyses of human milk fatty acids, phospholipids, and choline in association with cognition and temperament traits during the first 6 months of lifeTengfei Li0Tengfei Li1Tinu M. Samuel2Ziliang Zhu3Brittany Howell4Seoyoon Cho5Kristine Baluyot6Heather Hazlett7Jed T. Elison8Di Wu9Jonas Hauser10Norbert Sprenger11Hongtu Zhu12Hongtu Zhu13Weili Lin14Weili Lin15Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesBiomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesNestlé Product Technology Center-Nutrition, Société des Produits Nestlé S.A., Vevey, SwitzerlandDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesDepartment of Human Development and Family Science, Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Polytechnic Institute and State University, Roanoke, VA, United StatesDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesBiomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesInstitute of Child Development, University of Minnesota, Minneapolis, MN, United StatesDivision of Oral and Craniofacial Health Science, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesNestlé Institute of Health Sciences, Société des Produits Nestlé SA, Lausanne, SwitzerlandNestlé Institute of Health Sciences, Société des Produits Nestlé SA, Lausanne, SwitzerlandBiomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesBiomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United StatesEarly dietary exposure via human milk nutrients offers a window of opportunity to support cognitive and temperament development. While several studies have focused on associations of few pre-selected human milk nutrients with cognition and temperament, it is highly plausible that human milk nutrients synergistically and jointly support cognitive and behavioral development in early life. We aimed to discern the combined associations of three major classes of human milk nutrients with cognition and temperament during the first 6 months of life when human milk is the primary source of an infant’s nutrition and explore whether there were persistent effects up to 18 months old. The Mullen Scales of Early Learning and Infant Behavior Questionnaires—Revised were used to assess cognition and temperament, respectively, of 54 exclusively/predominantly breastfed infants in the first 6 months of life, whose follow-ups were conducted at 6–9, 9–12, and 12–18 months old. Human milk samples were obtained from the mothers of the participants at less than 6 months of age and analyzed for fatty acids [total monounsaturated fatty acids, polyunsaturated fatty acid, total saturated fatty acid (TSFA), arachidonic acid (ARA), docosahexaenoic acid (DHA), ARA/DHA, omega-6/omega-3 polyunsaturated fatty acids ratio (n-6/n-3)], phospholipids [phosphatidylcholine, phosphatidylethanolamine (PE), phosphatidylinositol (PI), sphingomyelin], and choline [free choline, phosphocholine (PCho), glycerophosphocholine]. Feature selection was performed to select nutrients associated with cognition and temperament. The combined effects of selected nutrients were analyzed using multiple regression. A positive association between the arachidonic acid (ARA) and surgency was observed (p = 0.024). A significant effect of DHA, n-6/n-3, PE, and TSFA concentrations on receptive language (R2 = 0.39, p = 0.025) and the elevated ARA, PCho, and PI with increased surgency (R2 = 0.43, p = 0.003) was identified, suggesting that DHA and ARA may have distinct roles for temperament and language functions. Furthermore, the exploratory association analyses suggest that the effects of human milk nutrients on R.L. and surgency may persist beyond the first 6 months of life, particularly surgency at 12–18 months (p = 0.002). Our study highlighted that various human milk nutrients work together to support the development of cognition and temperament traits during early infancy.https://www.frontiersin.org/articles/10.3389/fnut.2022.919769/fullhuman milkcognition and temperamentMullen Scales of Early LearningIBQreceptive languagesurgency |
| spellingShingle | Tengfei Li Tengfei Li Tinu M. Samuel Ziliang Zhu Brittany Howell Seoyoon Cho Kristine Baluyot Heather Hazlett Jed T. Elison Di Wu Jonas Hauser Norbert Sprenger Hongtu Zhu Hongtu Zhu Weili Lin Weili Lin Joint analyses of human milk fatty acids, phospholipids, and choline in association with cognition and temperament traits during the first 6 months of life Frontiers in Nutrition human milk cognition and temperament Mullen Scales of Early Learning IBQ receptive language surgency |
| title | Joint analyses of human milk fatty acids, phospholipids, and choline in association with cognition and temperament traits during the first 6 months of life |
| title_full | Joint analyses of human milk fatty acids, phospholipids, and choline in association with cognition and temperament traits during the first 6 months of life |
| title_fullStr | Joint analyses of human milk fatty acids, phospholipids, and choline in association with cognition and temperament traits during the first 6 months of life |
| title_full_unstemmed | Joint analyses of human milk fatty acids, phospholipids, and choline in association with cognition and temperament traits during the first 6 months of life |
| title_short | Joint analyses of human milk fatty acids, phospholipids, and choline in association with cognition and temperament traits during the first 6 months of life |
| title_sort | joint analyses of human milk fatty acids phospholipids and choline in association with cognition and temperament traits during the first 6 months of life |
| topic | human milk cognition and temperament Mullen Scales of Early Learning IBQ receptive language surgency |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.919769/full |
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