Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma
Redox dysregulation and oxidative stress have been implicated in asthma pathogenesis. Exercise interventions improve symptoms and reduce inflammation in asthma patients, but the underlying mechanisms remain unclear. We hypothesized that a personalised exercise intervention would improve asthma contr...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/12/1926 |
| _version_ | 1797506870785605632 |
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| author | Anna Freeman Doriana Cellura Magdalena Minnion Bernadette O. Fernandez Cosma Mirella Spalluto Denny Levett Andrew Bates Timothy Wallis Alastair Watson Sandy Jack Karl J. Staples Michael P. W. Grocott Martin Feelisch Tom M. A. Wilkinson |
| author_facet | Anna Freeman Doriana Cellura Magdalena Minnion Bernadette O. Fernandez Cosma Mirella Spalluto Denny Levett Andrew Bates Timothy Wallis Alastair Watson Sandy Jack Karl J. Staples Michael P. W. Grocott Martin Feelisch Tom M. A. Wilkinson |
| author_sort | Anna Freeman |
| collection | DOAJ |
| description | Redox dysregulation and oxidative stress have been implicated in asthma pathogenesis. Exercise interventions improve symptoms and reduce inflammation in asthma patients, but the underlying mechanisms remain unclear. We hypothesized that a personalised exercise intervention would improve asthma control by reducing lung inflammation through modulation of local and systemic reactive species interactions, thereby increasing antioxidant capacity. We combined deep redox metabolomic profiling with clinical assessment in an exploratory cohort of six female patients with symptomatic asthma and studied their responses to a metabolically targeted exercise intervention over 12 weeks. Plasma antioxidant capacity and circulating nitrite levels increased following the intervention (<i>p</i> = 0.028) and lowered the ratio of reduced to oxidised glutathione (<i>p</i> = 0.029); this was accompanied by improvements in physical fitness (<i>p</i> = 0.046), symptoms scores (<i>p</i> = 0.020), quality of life (<i>p</i> = 0.046), lung function (<i>p</i> = 0.028), airway hyperreactivity (<i>p</i> = 0.043), and eosinophilic inflammation (<i>p</i> = 0.007). Increased physical fitness correlated with improved plasma antioxidant capacity (<i>p</i> = 0.019), peak oxygen uptake and nitrite changes (<i>p</i> = 0.005), the latter also associated with reductions in peripheral blood eosinophil counts (<i>p</i> = 0.038). Thus, increases in “redox resilience” may underpin the clinical benefits of exercise in asthma. An improved understanding of exercise-induced alterations in redox regulation offers opportunities for greater treatment personalisation and identification of new treatment targets. |
| first_indexed | 2024-03-10T04:38:35Z |
| format | Article |
| id | doaj.art-6966a5e69d804666a0b1f3956220dc2a |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T04:38:35Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-6966a5e69d804666a0b1f3956220dc2a2023-11-23T03:33:00ZengMDPI AGAntioxidants2076-39212021-11-011012192610.3390/antiox10121926Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in AsthmaAnna Freeman0Doriana Cellura1Magdalena Minnion2Bernadette O. Fernandez3Cosma Mirella Spalluto4Denny Levett5Andrew Bates6Timothy Wallis7Alastair Watson8Sandy Jack9Karl J. Staples10Michael P. W. Grocott11Martin Feelisch12Tom M. A. Wilkinson13Clinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKClinical and Experimental Sciences and Southampton Centre for Biomedical Research, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UKRedox dysregulation and oxidative stress have been implicated in asthma pathogenesis. Exercise interventions improve symptoms and reduce inflammation in asthma patients, but the underlying mechanisms remain unclear. We hypothesized that a personalised exercise intervention would improve asthma control by reducing lung inflammation through modulation of local and systemic reactive species interactions, thereby increasing antioxidant capacity. We combined deep redox metabolomic profiling with clinical assessment in an exploratory cohort of six female patients with symptomatic asthma and studied their responses to a metabolically targeted exercise intervention over 12 weeks. Plasma antioxidant capacity and circulating nitrite levels increased following the intervention (<i>p</i> = 0.028) and lowered the ratio of reduced to oxidised glutathione (<i>p</i> = 0.029); this was accompanied by improvements in physical fitness (<i>p</i> = 0.046), symptoms scores (<i>p</i> = 0.020), quality of life (<i>p</i> = 0.046), lung function (<i>p</i> = 0.028), airway hyperreactivity (<i>p</i> = 0.043), and eosinophilic inflammation (<i>p</i> = 0.007). Increased physical fitness correlated with improved plasma antioxidant capacity (<i>p</i> = 0.019), peak oxygen uptake and nitrite changes (<i>p</i> = 0.005), the latter also associated with reductions in peripheral blood eosinophil counts (<i>p</i> = 0.038). Thus, increases in “redox resilience” may underpin the clinical benefits of exercise in asthma. An improved understanding of exercise-induced alterations in redox regulation offers opportunities for greater treatment personalisation and identification of new treatment targets.https://www.mdpi.com/2076-3921/10/12/1926asthmaexerciseoxidative stressreactive species interactomeinflammation |
| spellingShingle | Anna Freeman Doriana Cellura Magdalena Minnion Bernadette O. Fernandez Cosma Mirella Spalluto Denny Levett Andrew Bates Timothy Wallis Alastair Watson Sandy Jack Karl J. Staples Michael P. W. Grocott Martin Feelisch Tom M. A. Wilkinson Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma Antioxidants asthma exercise oxidative stress reactive species interactome inflammation |
| title | Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma |
| title_full | Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma |
| title_fullStr | Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma |
| title_full_unstemmed | Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma |
| title_short | Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma |
| title_sort | exercise training induces a shift in extracellular redox status with alterations in the pulmonary and systemic redox landscape in asthma |
| topic | asthma exercise oxidative stress reactive species interactome inflammation |
| url | https://www.mdpi.com/2076-3921/10/12/1926 |
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