HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

Neurologic disease caused by human immunodeficiency virus type 1 (HIV-1) is ultimately refractory to highly active antiretroviral therapy (HAART) because of failure of complete virus eradication in the central nervous system (CNS), and disruption of normal neural signaling events by virally induced...

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Bibliographic Details
Main Authors: John P Norman, Seth W Perry, Holly M Reynolds, Michelle Kiebala, Karen L De Mesy Bentley, Margarita Trejo, David J Volsky, Sanjay B Maggirwar, Stephen Dewhurst, Eliezer Masliah, Harris A Gelbard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2579580?pdf=render

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