Development of a minimally invasive simultaneous estimation method for quantifying translocator protein binding with [18F]FEPPA positron emission tomography

Development of a minimally invasive simultaneous estimation method for quantifying translocator protein binding with [18F]FEPPA positron emission tomography

Abstract Background The purpose of this study was to assess the feasibility of using a minimally invasive simultaneous estimation method (SIME) to quantify the binding of the 18-kDa translocator protein tracer [18F]FEPPA. Arterial sampling was avoided by extracting an image-derived input function (I...

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Bibliographic Details
Main Authors: Praveen Dassanayake, Udunna C. Anazodo, Linshan Liu, Lucas Narciso, Maryssa Iacobelli, Justin Hicks, Pablo Rusjan, Elizabeth Finger, Keith St Lawrence
Format: Article
Language:English
Published: SpringerOpen 2023-01-01
Series:EJNMMI Research
Subjects:
Positron emission tomography
PET/MR
Translocator protein (TSPO) imaging
Simultaneous estimation method
Kinetic modeling
Image-derived input function
Online Access:https://doi.org/10.1186/s13550-023-00950-1

Internet

https://doi.org/10.1186/s13550-023-00950-1

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