Correlation of biochemical profile at admission with severity and outcome of COVID-19
Background COVID-19 was detected in China in December 2019. The rapid dissemination and novelty of the disease resulted in an epidemic. This study aimed to identify biochemical parameters at admission that can be used to categorize severity and outcome of COVID −19 infection. Materials and Methods T...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Greater Baltimore Medical Center
2021-11-01
|
| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20009666.2021.1974161 |
| _version_ | 1828077271514087424 |
|---|---|
| author | Abdullah Sadiq Muhammad Khurram Javaria Malik Noman Ahmed Chaudhary Muhammad Mujeeb Khan Tahira Yasmeen Hamza Waqar Bhatti |
| author_facet | Abdullah Sadiq Muhammad Khurram Javaria Malik Noman Ahmed Chaudhary Muhammad Mujeeb Khan Tahira Yasmeen Hamza Waqar Bhatti |
| author_sort | Abdullah Sadiq |
| collection | DOAJ |
| description | Background COVID-19 was detected in China in December 2019. The rapid dissemination and novelty of the disease resulted in an epidemic. This study aimed to identify biochemical parameters at admission that can be used to categorize severity and outcome of COVID −19 infection. Materials and Methods This cross-sectional study was conducted at Allied Hospitals of RMU from April 2020 to July 2020. It included 128 randomly selected confirmed COVID-19 patients. At admission, biochemical profile (total bilirubin, alanine aminotransferases {ALT}, aspartate aminotransferases {AST}, urea, creatinine, uric acid, sodium, potassium, and chloride were correlated with severity and outcome of COVID-19 by employing t-tests and ANOVA where required. Cut-off values to predict disease severity and outcome were calculated using ROC curve. Results The study comprised 46.1% non-severe, 29.7% severe, and 24.2% critical COVID-19 patients. 84.4% patients improved and 15.6% expired. Urea was increased in critical disease patients (p < 0.000). Higher ALT (p 0.030) and AST (p 0.004) levels were noted in severe and critical disease. Sodium (p 0.001) and chloride (p 0.026) were decreased in critical disease. Patients who expired had increased urea (p 0.000), ALT (p 0.040) and AST (p 0.002). At admission, urea >42.7 mg (sensitivity of 64.7%, specificity of 87.5%), AST >43.5 IU/L (64% sensitivity, 60% specificity), and sodium <136.9 mmol/L (sensitivity of 70.6%, specificity of 71.2%) predicted critical COVID-19 infection. Conclusion At admission, increased urea, AST, and ALT along with decreased sodium can help in identifying COVID-19 patients with severe illness and poor outcome. |
| first_indexed | 2024-04-11T02:26:57Z |
| format | Article |
| id | doaj.art-696af91c745f4532a8453a521f43f5c2 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T02:26:57Z |
| publishDate | 2021-11-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-696af91c745f4532a8453a521f43f5c22023-01-02T22:33:45ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662021-11-0111674074610.1080/20009666.2021.19741611974161Correlation of biochemical profile at admission with severity and outcome of COVID-19Abdullah Sadiq0Muhammad Khurram1Javaria Malik2Noman Ahmed Chaudhary3Muhammad Mujeeb Khan4Tahira Yasmeen5Hamza Waqar Bhatti6Rawalpindi Medical UniversityRawalpindi Medical UniversityRawalpindi Medical UniversityRawalpindi Medical UniversityRawalpindi Medical UniversityRawalpindi Medical UniversityRawalpindi Medical UniversityBackground COVID-19 was detected in China in December 2019. The rapid dissemination and novelty of the disease resulted in an epidemic. This study aimed to identify biochemical parameters at admission that can be used to categorize severity and outcome of COVID −19 infection. Materials and Methods This cross-sectional study was conducted at Allied Hospitals of RMU from April 2020 to July 2020. It included 128 randomly selected confirmed COVID-19 patients. At admission, biochemical profile (total bilirubin, alanine aminotransferases {ALT}, aspartate aminotransferases {AST}, urea, creatinine, uric acid, sodium, potassium, and chloride were correlated with severity and outcome of COVID-19 by employing t-tests and ANOVA where required. Cut-off values to predict disease severity and outcome were calculated using ROC curve. Results The study comprised 46.1% non-severe, 29.7% severe, and 24.2% critical COVID-19 patients. 84.4% patients improved and 15.6% expired. Urea was increased in critical disease patients (p < 0.000). Higher ALT (p 0.030) and AST (p 0.004) levels were noted in severe and critical disease. Sodium (p 0.001) and chloride (p 0.026) were decreased in critical disease. Patients who expired had increased urea (p 0.000), ALT (p 0.040) and AST (p 0.002). At admission, urea >42.7 mg (sensitivity of 64.7%, specificity of 87.5%), AST >43.5 IU/L (64% sensitivity, 60% specificity), and sodium <136.9 mmol/L (sensitivity of 70.6%, specificity of 71.2%) predicted critical COVID-19 infection. Conclusion At admission, increased urea, AST, and ALT along with decreased sodium can help in identifying COVID-19 patients with severe illness and poor outcome.http://dx.doi.org/10.1080/20009666.2021.1974161coronavirusalanine aminotransferaseaspartate aminotransferaseureasodium |
| spellingShingle | Abdullah Sadiq Muhammad Khurram Javaria Malik Noman Ahmed Chaudhary Muhammad Mujeeb Khan Tahira Yasmeen Hamza Waqar Bhatti Correlation of biochemical profile at admission with severity and outcome of COVID-19 Journal of Community Hospital Internal Medicine Perspectives coronavirus alanine aminotransferase aspartate aminotransferase urea sodium |
| title | Correlation of biochemical profile at admission with severity and outcome of COVID-19 |
| title_full | Correlation of biochemical profile at admission with severity and outcome of COVID-19 |
| title_fullStr | Correlation of biochemical profile at admission with severity and outcome of COVID-19 |
| title_full_unstemmed | Correlation of biochemical profile at admission with severity and outcome of COVID-19 |
| title_short | Correlation of biochemical profile at admission with severity and outcome of COVID-19 |
| title_sort | correlation of biochemical profile at admission with severity and outcome of covid 19 |
| topic | coronavirus alanine aminotransferase aspartate aminotransferase urea sodium |
| url | http://dx.doi.org/10.1080/20009666.2021.1974161 |
| work_keys_str_mv | AT abdullahsadiq correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 AT muhammadkhurram correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 AT javariamalik correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 AT nomanahmedchaudhary correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 AT muhammadmujeebkhan correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 AT tahirayasmeen correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 AT hamzawaqarbhatti correlationofbiochemicalprofileatadmissionwithseverityandoutcomeofcovid19 |