Down Syndrome and Thyroid Gland
Down Syndrome (DS) or trisomy 21 (T21) is the most frequent and the best known malformation syndrome associated with mental deficiency that appears in human,. Average incidence of this syndrome is about 1:700 newborns. Numerous researchers noted thyroid disorders in people with Down Syndrome but, c...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2006-08-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3142 |
| _version_ | 1827317243342487552 |
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| author | Mensuda Hasanhodžić Husref Tahirović Ljerka Lukinac |
| author_facet | Mensuda Hasanhodžić Husref Tahirović Ljerka Lukinac |
| author_sort | Mensuda Hasanhodžić |
| collection | DOAJ |
| description |
Down Syndrome (DS) or trisomy 21 (T21) is the most frequent and the best known malformation syndrome associated with mental deficiency that appears in human,. Average incidence of this syndrome is about 1:700 newborns. Numerous researchers noted thyroid disorders in people with Down Syndrome but, clinical symptoms of thyroid dysfunction are difficult to separate from DS phenotype. The aim of this study was to examine the thyroid function in the patients with DS. Our results confirmed higher frequency of thyroid dysfunction in DS patients. Higher values of TSH were found in 60,34% of the examined DS patients, which is significantly higher value comparing with the control group (p<0,01). Compensated hypothyroidism was established in 27,92% of the examined DS patients, and most of those (63,23%) were younger than 6 years. The conclusions emphasize the necessity of implementation of thyroid function screening program in persons with DS, and the need for adequate treatment of its dysfunction. Thus, the symptoms of the disease would be alleviated and better physical and mental fitness ensured.
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| first_indexed | 2024-04-24T23:31:00Z |
| format | Article |
| id | doaj.art-696b7c47379246ad9a0361d57dac2a45 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:31:00Z |
| publishDate | 2006-08-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-696b7c47379246ad9a0361d57dac2a452024-03-15T14:42:31ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2006-08-016310.17305/bjbms.2006.3142694Down Syndrome and Thyroid GlandMensuda Hasanhodžić0Husref Tahirović1Ljerka Lukinac2Department of Pediatrics, University Clinics Center TuzlaDepartment of Pediatrics, University Clinics Center TuzlaDepartment of Pediatrics, University Clinics Center Tuzla Down Syndrome (DS) or trisomy 21 (T21) is the most frequent and the best known malformation syndrome associated with mental deficiency that appears in human,. Average incidence of this syndrome is about 1:700 newborns. Numerous researchers noted thyroid disorders in people with Down Syndrome but, clinical symptoms of thyroid dysfunction are difficult to separate from DS phenotype. The aim of this study was to examine the thyroid function in the patients with DS. Our results confirmed higher frequency of thyroid dysfunction in DS patients. Higher values of TSH were found in 60,34% of the examined DS patients, which is significantly higher value comparing with the control group (p<0,01). Compensated hypothyroidism was established in 27,92% of the examined DS patients, and most of those (63,23%) were younger than 6 years. The conclusions emphasize the necessity of implementation of thyroid function screening program in persons with DS, and the need for adequate treatment of its dysfunction. Thus, the symptoms of the disease would be alleviated and better physical and mental fitness ensured. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3142down syndromethyroid gland |
| spellingShingle | Mensuda Hasanhodžić Husref Tahirović Ljerka Lukinac Down Syndrome and Thyroid Gland Biomolecules & Biomedicine down syndrome thyroid gland |
| title | Down Syndrome and Thyroid Gland |
| title_full | Down Syndrome and Thyroid Gland |
| title_fullStr | Down Syndrome and Thyroid Gland |
| title_full_unstemmed | Down Syndrome and Thyroid Gland |
| title_short | Down Syndrome and Thyroid Gland |
| title_sort | down syndrome and thyroid gland |
| topic | down syndrome thyroid gland |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3142 |
| work_keys_str_mv | AT mensudahasanhodzic downsyndromeandthyroidgland AT husreftahirovic downsyndromeandthyroidgland AT ljerkalukinac downsyndromeandthyroidgland |