Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms
Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on their cell surface. Due to this, SSTR and somatos...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/12/1810 |
| _version_ | 1797506513572462592 |
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| author | Maria Isabel del Olmo-Garcia Stefan Prado-Wohlwend Alexia Andres Jose M. Soriano Pilar Bello Juan Francisco Merino-Torres |
| author_facet | Maria Isabel del Olmo-Garcia Stefan Prado-Wohlwend Alexia Andres Jose M. Soriano Pilar Bello Juan Francisco Merino-Torres |
| author_sort | Maria Isabel del Olmo-Garcia |
| collection | DOAJ |
| description | Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on their cell surface. Due to this, SSTR and somatostatin have been a large subject of interest in the discovery of potential biomarkers and treatment options for the disease. The aim of this review is to describe the molecular characteristics of somatostatin and somatostatin receptors and its application in diagnosis and therapy on patients with NENs as well as the use in the near future of somatostatin antagonists. |
| first_indexed | 2024-03-10T04:33:43Z |
| format | Article |
| id | doaj.art-696ca5ab84b64d53ae560dd0193bf3a8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T04:33:43Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-696ca5ab84b64d53ae560dd0193bf3a82023-11-23T03:55:55ZengMDPI AGBiomedicines2227-90592021-12-01912181010.3390/biomedicines9121810Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine NeoplasmsMaria Isabel del Olmo-Garcia0Stefan Prado-Wohlwend1Alexia Andres2Jose M. Soriano3Pilar Bello4Juan Francisco Merino-Torres5Endocrinology and Nutrition Department, University and Politecnic Hospital La Fe (Valencia), 46026 Valencia, SpainNuclear Medicine Department, University and Politecnic Hospital La Fe (Valencia), 46026 Valencia, SpainEndocrinology and Nutrition Department, University and Politecnic Hospital La Fe (Valencia), 46026 Valencia, SpainJoint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia-Health Research Institute La Fe, 46026 Valencia, SpainNuclear Medicine Department, University and Politecnic Hospital La Fe (Valencia), 46026 Valencia, SpainEndocrinology and Nutrition Department, University and Politecnic Hospital La Fe (Valencia), 46026 Valencia, SpainNeuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on their cell surface. Due to this, SSTR and somatostatin have been a large subject of interest in the discovery of potential biomarkers and treatment options for the disease. The aim of this review is to describe the molecular characteristics of somatostatin and somatostatin receptors and its application in diagnosis and therapy on patients with NENs as well as the use in the near future of somatostatin antagonists.https://www.mdpi.com/2227-9059/9/12/1810neuroendocrine neoplasmssomatostatin receptorspeptide receptor radionuclide therapysomatostatin analoguessomatostatin antagonists68Ga PET |
| spellingShingle | Maria Isabel del Olmo-Garcia Stefan Prado-Wohlwend Alexia Andres Jose M. Soriano Pilar Bello Juan Francisco Merino-Torres Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms Biomedicines neuroendocrine neoplasms somatostatin receptors peptide receptor radionuclide therapy somatostatin analogues somatostatin antagonists 68Ga PET |
| title | Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms |
| title_full | Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms |
| title_fullStr | Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms |
| title_full_unstemmed | Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms |
| title_short | Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms |
| title_sort | somatostatin and somatostatin receptors from signaling to clinical applications in neuroendocrine neoplasms |
| topic | neuroendocrine neoplasms somatostatin receptors peptide receptor radionuclide therapy somatostatin analogues somatostatin antagonists 68Ga PET |
| url | https://www.mdpi.com/2227-9059/9/12/1810 |
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