Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway

Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway

Context Cisplatin-based chemotherapy was widely used in treating human malignancies. However, side effects and chemoresistance remains the major obstacle. Objective To verify whether natural borneol (NB) can enhance cisplatin-induced glioma cell apoptosis and explore the mechanism. Materials and met...

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Bibliographic Details
Main Authors: Wen-qiang Cao, Xiao-qian Zhai, Ji-wei Ma, Xue-qi Fu, Bai-song Zhao, Pu Zhang, Xiao-yan Fu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Pharmaceutical Biology
Subjects:
chemo-sensitization
dna damage
reactive oxygen species
p53
erk
akt
Online Access:http://dx.doi.org/10.1080/13880209.2019.1703756

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