Single-cell and spatial transcriptomics reveal 5-methylcytosine RNA methylation regulators immunologically reprograms tumor microenvironment characterizations, immunotherapy response and precision treatment of clear cell renal cell carcinoma

Single-cell and spatial transcriptomics reveal 5-methylcytosine RNA methylation regulators immunologically reprograms tumor microenvironment characterizations, immunotherapy response and precision treatment of clear cell renal cell carcinoma

Clear cell Renal Cell Carcinoma (ccRCC) is a highly heterogeneous disease, making it challenging to predict prognosis and therapy efficacy. In this study, we aimed to explore the role of 5-methylcytosine (m5C) RNA modification in ccRCC and its potential as a predictor for therapy response and overal...

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Bibliographic Details
Main Authors: Cheng-Peng Gui, Jin-Huan Wei, Chi Zhang, Yi-Ming Tang, Guan-Nan Shu, Rong-Pei Wu, Jun-Hang Luo
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Translational Oncology
Subjects:
Clear cell renal cell carcinoma
m5C RNA modification
Single-cell transcriptomics
Spatial transcriptomics
Tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323001122

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