<i>Osmunda japonica</i> Extract Suppresses Pro-Inflammatory Cytokines by Downregulating NF-κB Activation in Periodontal Ligament Fibroblasts Infected with Oral Pathogenic Bacteria
Periodontal diseases are caused by bacterial infection and may progress to chronic dental disease; severe inflammation may result in bone loss. Therefore, it is necessary to prevent bacterial infection or control inflammation. Periodontal ligament fibroblasts (PDLFs) are responsible for the maintena...
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2020-04-01
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author | Jihyoun Seong Jinkyung Lee Yun Kyong Lim Weon-Jong Yoon Seunggon Jung Joong-Ki Kook Tae-Hoon Lee |
author_facet | Jihyoun Seong Jinkyung Lee Yun Kyong Lim Weon-Jong Yoon Seunggon Jung Joong-Ki Kook Tae-Hoon Lee |
author_sort | Jihyoun Seong |
collection | DOAJ |
description | Periodontal diseases are caused by bacterial infection and may progress to chronic dental disease; severe inflammation may result in bone loss. Therefore, it is necessary to prevent bacterial infection or control inflammation. Periodontal ligament fibroblasts (PDLFs) are responsible for the maintenance of tissue integrity and immune and inflammatory events in periodontal diseases. The formation of bacterial complexes by <i>Fusobacterium nucleatum</i> and <i>Porphyromonas gingivalis</i> is crucial in the pathogenesis of periodontal disease. <i>F. nucleatum</i> is a facultative anaerobic species, considered to be a key mediator of dental plaque maturation and aggregation of other oral bacteria. <i>P. gingivalis</i> is an obligate anaerobic species that induces gingival inflammation by secreting virulence factors. In this study, we investigated whether <i>Osmunda japonica</i> extract exerted anti-inflammatory effects in primary PDLFs stimulated by oral pathogens. PDLFs were stimulated with <i>F. nucleatum</i> or <i>P. gingivalis</i>. We showed that pro-inflammatory cytokine (IL-6 and IL-8) expression was induced by LPS or bacterial infection but decreased by treatment with <i>O. japonica</i> extract following bacterial infection. We found that the activation of NF-κB, a transcription factor for pro-inflammatory cytokines, was modulated by <i>O. japonica</i> extract. Thus, <i>O. japonica</i> extract has immunomodulatory activity that can be harnessed to control inflammation. |
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spelling | doaj.art-696f5095600e4855bcad382b9de6a5ee2023-11-19T20:25:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01217245310.3390/ijms21072453<i>Osmunda japonica</i> Extract Suppresses Pro-Inflammatory Cytokines by Downregulating NF-κB Activation in Periodontal Ligament Fibroblasts Infected with Oral Pathogenic BacteriaJihyoun Seong0Jinkyung Lee1Yun Kyong Lim2Weon-Jong Yoon3Seunggon Jung4Joong-Ki Kook5Tae-Hoon Lee6Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, KoreaDepartment of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, KoreaDepartment of Oral Biochemistry, School of Dentistry, Chosun University, Gwangju 61452, KoreaJeju Biodiversity Research Institute (JBRI), Jeju Technopark (JTP), Jeju 63608, KoreaDepartment of Oral & Maxillofacial Surgery, School of Dentistry, Chonnam National University, Gwangju 61186, KoreaDepartment of Oral Biochemistry, School of Dentistry, Chosun University, Gwangju 61452, KoreaDepartment of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, KoreaPeriodontal diseases are caused by bacterial infection and may progress to chronic dental disease; severe inflammation may result in bone loss. Therefore, it is necessary to prevent bacterial infection or control inflammation. Periodontal ligament fibroblasts (PDLFs) are responsible for the maintenance of tissue integrity and immune and inflammatory events in periodontal diseases. The formation of bacterial complexes by <i>Fusobacterium nucleatum</i> and <i>Porphyromonas gingivalis</i> is crucial in the pathogenesis of periodontal disease. <i>F. nucleatum</i> is a facultative anaerobic species, considered to be a key mediator of dental plaque maturation and aggregation of other oral bacteria. <i>P. gingivalis</i> is an obligate anaerobic species that induces gingival inflammation by secreting virulence factors. In this study, we investigated whether <i>Osmunda japonica</i> extract exerted anti-inflammatory effects in primary PDLFs stimulated by oral pathogens. PDLFs were stimulated with <i>F. nucleatum</i> or <i>P. gingivalis</i>. We showed that pro-inflammatory cytokine (IL-6 and IL-8) expression was induced by LPS or bacterial infection but decreased by treatment with <i>O. japonica</i> extract following bacterial infection. We found that the activation of NF-κB, a transcription factor for pro-inflammatory cytokines, was modulated by <i>O. japonica</i> extract. Thus, <i>O. japonica</i> extract has immunomodulatory activity that can be harnessed to control inflammation.https://www.mdpi.com/1422-0067/21/7/2453<i>Fusobacterium nucleatum</i><i>Porphyromonas gingivalis</i>periodontal ligament fibroblast<i>Osmunda japonica</i>pro-inflammatory cytokines |
spellingShingle | Jihyoun Seong Jinkyung Lee Yun Kyong Lim Weon-Jong Yoon Seunggon Jung Joong-Ki Kook Tae-Hoon Lee <i>Osmunda japonica</i> Extract Suppresses Pro-Inflammatory Cytokines by Downregulating NF-κB Activation in Periodontal Ligament Fibroblasts Infected with Oral Pathogenic Bacteria International Journal of Molecular Sciences <i>Fusobacterium nucleatum</i> <i>Porphyromonas gingivalis</i> periodontal ligament fibroblast <i>Osmunda japonica</i> pro-inflammatory cytokines |
title | <i>Osmunda japonica</i> Extract Suppresses Pro-Inflammatory Cytokines by Downregulating NF-κB Activation in Periodontal Ligament Fibroblasts Infected with Oral Pathogenic Bacteria |
title_full | <i>Osmunda japonica</i> Extract Suppresses Pro-Inflammatory Cytokines by Downregulating NF-κB Activation in Periodontal Ligament Fibroblasts Infected with Oral Pathogenic Bacteria |
title_fullStr | <i>Osmunda japonica</i> Extract Suppresses Pro-Inflammatory Cytokines by Downregulating NF-κB Activation in Periodontal Ligament Fibroblasts Infected with Oral Pathogenic Bacteria |
title_full_unstemmed | <i>Osmunda japonica</i> Extract Suppresses Pro-Inflammatory Cytokines by Downregulating NF-κB Activation in Periodontal Ligament Fibroblasts Infected with Oral Pathogenic Bacteria |
title_short | <i>Osmunda japonica</i> Extract Suppresses Pro-Inflammatory Cytokines by Downregulating NF-κB Activation in Periodontal Ligament Fibroblasts Infected with Oral Pathogenic Bacteria |
title_sort | i osmunda japonica i extract suppresses pro inflammatory cytokines by downregulating nf κb activation in periodontal ligament fibroblasts infected with oral pathogenic bacteria |
topic | <i>Fusobacterium nucleatum</i> <i>Porphyromonas gingivalis</i> periodontal ligament fibroblast <i>Osmunda japonica</i> pro-inflammatory cytokines |
url | https://www.mdpi.com/1422-0067/21/7/2453 |
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