The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome
Many neurological disorders, including neurodevelopmental disorders, report hypersynchrony of neuronal networks. These alterations in neuronal synchronization suggest a link to the function of inhibitory interneurons. In Fragile X Syndrome (FXS), it has been reported that altered synchronization ma...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-08-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00245/full |
| _version_ | 1818509620875886592 |
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| author | Christian eCea-Del Rio Molly Maureen Huntsman |
| author_facet | Christian eCea-Del Rio Molly Maureen Huntsman |
| author_sort | Christian eCea-Del Rio |
| collection | DOAJ |
| description | Many neurological disorders, including neurodevelopmental disorders, report hypersynchrony of neuronal networks. These alterations in neuronal synchronization suggest a link to the function of inhibitory interneurons. In Fragile X Syndrome (FXS), it has been reported that altered synchronization may underlie hyperexcitability, cognitive dysfunction and provide a link to the increased incidence of epileptic seizures. Therefore, understanding the roles of inhibitory interneurons and how they control neuronal networks is of great importance in studying neurodevelopmental disorders such as FXS. Here, we present a review of how interneuron populations and inhibition are important contributors to the loss of excitatory/inhibitory balance seen in hypersynchronous and hyperexcitable networks from neurodevelopmental disorders, and specifically in FXS. |
| first_indexed | 2024-12-10T22:47:54Z |
| format | Article |
| id | doaj.art-696fd62ee92a443e8aa3e4ac835aa386 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-10T22:47:54Z |
| publishDate | 2014-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-696fd62ee92a443e8aa3e4ac835aa3862022-12-22T01:30:31ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022014-08-01810.3389/fncel.2014.00245103584The contribution of inhibitory interneurons to circuit dysfunction in Fragile X SyndromeChristian eCea-Del Rio0Molly Maureen Huntsman1University of Colorado Denver Anschutz Medical CampusUniversity of Colorado Denver Anschutz Medical CampusMany neurological disorders, including neurodevelopmental disorders, report hypersynchrony of neuronal networks. These alterations in neuronal synchronization suggest a link to the function of inhibitory interneurons. In Fragile X Syndrome (FXS), it has been reported that altered synchronization may underlie hyperexcitability, cognitive dysfunction and provide a link to the increased incidence of epileptic seizures. Therefore, understanding the roles of inhibitory interneurons and how they control neuronal networks is of great importance in studying neurodevelopmental disorders such as FXS. Here, we present a review of how interneuron populations and inhibition are important contributors to the loss of excitatory/inhibitory balance seen in hypersynchronous and hyperexcitable networks from neurodevelopmental disorders, and specifically in FXS.http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00245/fullInterneuronsSynaptic TransmissionGABAsynchronizationinhibitory neurotransmission |
| spellingShingle | Christian eCea-Del Rio Molly Maureen Huntsman The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome Frontiers in Cellular Neuroscience Interneurons Synaptic Transmission GABA synchronization inhibitory neurotransmission |
| title | The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome |
| title_full | The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome |
| title_fullStr | The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome |
| title_full_unstemmed | The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome |
| title_short | The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome |
| title_sort | contribution of inhibitory interneurons to circuit dysfunction in fragile x syndrome |
| topic | Interneurons Synaptic Transmission GABA synchronization inhibitory neurotransmission |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00245/full |
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