Coptidis Rhizoma Suppresses Metastatic Behavior by Inhibiting TGF-β-Mediated Epithelial-Mesenchymal Transition in 5-FU-Resistant HCT116 Cells

Coptidis Rhizoma Suppresses Metastatic Behavior by Inhibiting TGF-β-Mediated Epithelial-Mesenchymal Transition in 5-FU-Resistant HCT116 Cells

Colorectal cancer (CRC) is the second most lethal malignancy worldwide. The high mortality rate of CRC is largely due to cancer metastasis. Recently, suppressing epithelial-to-mesenchymal transition (EMT) has been considered a promising strategy for treating metastatic cancer, especially drug-resist...

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Bibliographic Details
Main Authors: Yong-Hwi Kang, Jing-Hua Wang, Jin-Seok Lee, Nam-Hun Lee, Chang-Gue Son
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
colorectal cancer
metastasis
5-fluorouracil
EMT
coptidis rhizoma
TGF-β
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.909331/full

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