Effect of Revascularization on Exercise-Induced Changes in Cardiac and Prothrombotic Biomarkers in Patients with Coronary Artery Disease
We examined whether resting levels and exercise-induced changes during exercise ECG stress test (EST) of cardiac Troponin T (cTnT), NT-proBNP and prothrombotic markers were affected by revascularization in patients with coronary artery disease (CAD). EST1 was performed before coronary angiography an...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-04-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296221094029 |
| _version_ | 1818049183057182720 |
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| author | C. H. Hansen RA J. Cwikiel MD V. Bratseth MSc, PhD H. Arnesen MD, PhD A. Flaa MD, PhD I. Seljeflot PhD |
| author_facet | C. H. Hansen RA J. Cwikiel MD V. Bratseth MSc, PhD H. Arnesen MD, PhD A. Flaa MD, PhD I. Seljeflot PhD |
| author_sort | C. H. Hansen RA |
| collection | DOAJ |
| description | We examined whether resting levels and exercise-induced changes during exercise ECG stress test (EST) of cardiac Troponin T (cTnT), NT-proBNP and prothrombotic markers were affected by revascularization in patients with coronary artery disease (CAD). EST1 was performed before coronary angiography and revascularization, and patients (n = 20) with confirmed CAD, performed another EST (EST2) 9 weeks later. Blood samples were drawn at rest and within five min after termination of ESTs. cTnT and NT-proBNP increased during exercise at both ESTs (p < 0.001, all). Resting cTnT levels at EST2 versus EST1 were significantly higher (p = 0.02) whereas NT-proBNP did not differ. At both visits, increased D-dimer (p = 0.008 and <0.001), pro-thrombin fragment 1 + 2 (p = 0.009 and 0.001) and tissue factor pathway inhibitor (TFPI) (p < 0.001 and 0.001) during exercise were demonstrated. Resting levels of endogenous thrombin potential (ETP) and TFPI were reduced at EST2 versus EST1 (p < 0.01). Revascularization did not affect exercise-induced release of cardiac and prothrombotic biomarkers and did not reduce resting levels of cTnT or NT-proBNP, suggesting revascularization per se not to prevent secretion of biomarkers. The lower resting levels of ETP and TFPI after revascularization may however, be indicative of reduced thrombin generation and endothelial activation. Clinicaltrials.gov, CADENCE, NCT01495091 https://clinicaltrials.gov/ct2/show/NCT01495091?term = 01495091&draw = 2&rank = 1 . |
| first_indexed | 2024-12-10T10:33:31Z |
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| id | doaj.art-696ffcdc9f45416b99314d6a67a82c2d |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-10T10:33:31Z |
| publishDate | 2022-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-696ffcdc9f45416b99314d6a67a82c2d2022-12-22T01:52:30ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232022-04-012810.1177/10760296221094029Effect of Revascularization on Exercise-Induced Changes in Cardiac and Prothrombotic Biomarkers in Patients with Coronary Artery DiseaseC. H. Hansen RA0J. Cwikiel MD1V. Bratseth MSc, PhD2H. Arnesen MD, PhD3A. Flaa MD, PhD4I. Seljeflot PhD5 Department of Cardiology, , Ullevaal, Norway Center for Clinical Heart Research, , Ullevaal, Norway Department of Cardiology, , Ullevaal, Norway Faculty of Medicine, University of Oslo, Oslo, Norway Department of Cardiology, , Ullevaal, Norway Faculty of Medicine, University of Oslo, Oslo, NorwayWe examined whether resting levels and exercise-induced changes during exercise ECG stress test (EST) of cardiac Troponin T (cTnT), NT-proBNP and prothrombotic markers were affected by revascularization in patients with coronary artery disease (CAD). EST1 was performed before coronary angiography and revascularization, and patients (n = 20) with confirmed CAD, performed another EST (EST2) 9 weeks later. Blood samples were drawn at rest and within five min after termination of ESTs. cTnT and NT-proBNP increased during exercise at both ESTs (p < 0.001, all). Resting cTnT levels at EST2 versus EST1 were significantly higher (p = 0.02) whereas NT-proBNP did not differ. At both visits, increased D-dimer (p = 0.008 and <0.001), pro-thrombin fragment 1 + 2 (p = 0.009 and 0.001) and tissue factor pathway inhibitor (TFPI) (p < 0.001 and 0.001) during exercise were demonstrated. Resting levels of endogenous thrombin potential (ETP) and TFPI were reduced at EST2 versus EST1 (p < 0.01). Revascularization did not affect exercise-induced release of cardiac and prothrombotic biomarkers and did not reduce resting levels of cTnT or NT-proBNP, suggesting revascularization per se not to prevent secretion of biomarkers. The lower resting levels of ETP and TFPI after revascularization may however, be indicative of reduced thrombin generation and endothelial activation. Clinicaltrials.gov, CADENCE, NCT01495091 https://clinicaltrials.gov/ct2/show/NCT01495091?term = 01495091&draw = 2&rank = 1 .https://doi.org/10.1177/10760296221094029 |
| spellingShingle | C. H. Hansen RA J. Cwikiel MD V. Bratseth MSc, PhD H. Arnesen MD, PhD A. Flaa MD, PhD I. Seljeflot PhD Effect of Revascularization on Exercise-Induced Changes in Cardiac and Prothrombotic Biomarkers in Patients with Coronary Artery Disease Clinical and Applied Thrombosis/Hemostasis |
| title | Effect of Revascularization on
Exercise-Induced Changes in Cardiac and Prothrombotic Biomarkers in Patients with Coronary Artery Disease |
| title_full | Effect of Revascularization on
Exercise-Induced Changes in Cardiac and Prothrombotic Biomarkers in Patients with Coronary Artery Disease |
| title_fullStr | Effect of Revascularization on
Exercise-Induced Changes in Cardiac and Prothrombotic Biomarkers in Patients with Coronary Artery Disease |
| title_full_unstemmed | Effect of Revascularization on
Exercise-Induced Changes in Cardiac and Prothrombotic Biomarkers in Patients with Coronary Artery Disease |
| title_short | Effect of Revascularization on
Exercise-Induced Changes in Cardiac and Prothrombotic Biomarkers in Patients with Coronary Artery Disease |
| title_sort | effect of revascularization on exercise induced changes in cardiac and prothrombotic biomarkers in patients with coronary artery disease |
| url | https://doi.org/10.1177/10760296221094029 |
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