Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United States
Tiffany P Quock,1 Tingjian Yan,2 Ryan Tieu,2 Anita D’Souza,3 Michael S Broder21Medical Affairs, Prothena Biosciences Inc, South San Francisco, CA, USA; 2Health Services Research, Partnership for Health Analytic Research, LLC, Beverly Hills, CA, USA; 3Division of Hematology and Oncology, Me...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-07-01
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| Series: | ClinicoEconomics and Outcomes Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/untangling-the-clinical-and-economic-burden-of-hospitalization-for-car-peer-reviewed-article-CEOR |
| _version_ | 1818126999155113984 |
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| author | Quock TP Yan T Tieu R D'Souza A Broder MS |
| author_facet | Quock TP Yan T Tieu R D'Souza A Broder MS |
| author_sort | Quock TP |
| collection | DOAJ |
| description | Tiffany P Quock,1 Tingjian Yan,2 Ryan Tieu,2 Anita D’Souza,3 Michael S Broder21Medical Affairs, Prothena Biosciences Inc, South San Francisco, CA, USA; 2Health Services Research, Partnership for Health Analytic Research, LLC, Beverly Hills, CA, USA; 3Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USAPurpose: Cardiac dysfunction is common in amyloid light-chain (AL) amyloidosis, a rare disease caused by extracellular deposition of misfolded immunoglobulin light chains. This study aimed to examine economic/clinical disease burden in hospitalized cardiac amyloidosis patients.Patients and methods: Cardiac amyloidosis patients ≥18 years old hospitalized between 2014 and 2016 were identified in claims if they had ≥1 inpatient claim consistent with amyloidosis and evidence of cardiac dysfunction. Descriptive statistics were reported.Results: 3239 cardiac amyloidosis patients [1795 (55.4%) with concurrent renal disease] were identified. Mean (SD) length of stay was 8.3 (11.1) days. 25.2% were admitted to the intensive care unit. Mean overall hospitalization costs were USD$20,584. In-hospital mortality was 9.0% overall. 16.8% were readmitted within 30 days, with 11.2% dying in-hospital and a mean readmission cost of USD$18,536.Conclusion: Hospitalization for cardiac amyloidosis is costly, with high rates of readmission and mortality. Opportunities exist to improve care.Keywords: cardiac amyloidosis, hospitalization, burden of illness, cost |
| first_indexed | 2024-12-11T07:10:23Z |
| format | Article |
| id | doaj.art-6970f7ccf88c49678550a148f085cedb |
| institution | Directory Open Access Journal |
| issn | 1178-6981 |
| language | English |
| last_indexed | 2024-12-11T07:10:23Z |
| publishDate | 2019-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | ClinicoEconomics and Outcomes Research |
| spelling | doaj.art-6970f7ccf88c49678550a148f085cedb2022-12-22T01:16:23ZengDove Medical PressClinicoEconomics and Outcomes Research1178-69812019-07-01Volume 1143143947124Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United StatesQuock TPYan TTieu RD'Souza ABroder MSTiffany P Quock,1 Tingjian Yan,2 Ryan Tieu,2 Anita D’Souza,3 Michael S Broder21Medical Affairs, Prothena Biosciences Inc, South San Francisco, CA, USA; 2Health Services Research, Partnership for Health Analytic Research, LLC, Beverly Hills, CA, USA; 3Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USAPurpose: Cardiac dysfunction is common in amyloid light-chain (AL) amyloidosis, a rare disease caused by extracellular deposition of misfolded immunoglobulin light chains. This study aimed to examine economic/clinical disease burden in hospitalized cardiac amyloidosis patients.Patients and methods: Cardiac amyloidosis patients ≥18 years old hospitalized between 2014 and 2016 were identified in claims if they had ≥1 inpatient claim consistent with amyloidosis and evidence of cardiac dysfunction. Descriptive statistics were reported.Results: 3239 cardiac amyloidosis patients [1795 (55.4%) with concurrent renal disease] were identified. Mean (SD) length of stay was 8.3 (11.1) days. 25.2% were admitted to the intensive care unit. Mean overall hospitalization costs were USD$20,584. In-hospital mortality was 9.0% overall. 16.8% were readmitted within 30 days, with 11.2% dying in-hospital and a mean readmission cost of USD$18,536.Conclusion: Hospitalization for cardiac amyloidosis is costly, with high rates of readmission and mortality. Opportunities exist to improve care.Keywords: cardiac amyloidosis, hospitalization, burden of illness, costhttps://www.dovepress.com/untangling-the-clinical-and-economic-burden-of-hospitalization-for-car-peer-reviewed-article-CEORcardiac amyloidosishospitalizationburden of illnesscost |
| spellingShingle | Quock TP Yan T Tieu R D'Souza A Broder MS Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United States ClinicoEconomics and Outcomes Research cardiac amyloidosis hospitalization burden of illness cost |
| title | Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United States |
| title_full | Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United States |
| title_fullStr | Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United States |
| title_full_unstemmed | Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United States |
| title_short | Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United States |
| title_sort | untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the united states |
| topic | cardiac amyloidosis hospitalization burden of illness cost |
| url | https://www.dovepress.com/untangling-the-clinical-and-economic-burden-of-hospitalization-for-car-peer-reviewed-article-CEOR |
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