Metal‐Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration
Abstract Osteoarthritis (OA) is a degenerative disease that often causes cartilage lesions and even osteochondral damage. Osteochondral defects induced by OA are accompanied by an inflammatory arthrosis microenvironment with overproduced reactive oxygen species (ROS), resulting in the exacerbation o...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-05-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202206875 |
| _version_ | 1827953613548290048 |
|---|---|
| author | Chaoqin Shu Chen Qin Lei Chen Yufeng Wang Zhe Shi Jiangming Yu Jimin Huang Chaoqian Zhao Zhiguang Huan Chengtie Wu Min Zhu Yufang Zhu |
| author_facet | Chaoqin Shu Chen Qin Lei Chen Yufeng Wang Zhe Shi Jiangming Yu Jimin Huang Chaoqian Zhao Zhiguang Huan Chengtie Wu Min Zhu Yufang Zhu |
| author_sort | Chaoqin Shu |
| collection | DOAJ |
| description | Abstract Osteoarthritis (OA) is a degenerative disease that often causes cartilage lesions and even osteochondral damage. Osteochondral defects induced by OA are accompanied by an inflammatory arthrosis microenvironment with overproduced reactive oxygen species (ROS), resulting in the exacerbation of defects and difficulty regenerating osteochondral tissues. Therefore, it is urgently needed to develop osteochondral scaffolds that can not only promote the integrated regeneration of cartilage and subchondral bone, but also possess ROS‐scavenging ability to protect tissues from oxidative stress. Herein, zinc‐cobalt bimetallic organic framework (Zn/Co‐MOF) functionalized bioceramic scaffolds are designed for repairing osteochondral defects under OA environment. By functionalizing Zn/Co‐MOF on the 3D‐printed beta‐tricalcium phosphate (β‐TCP) scaffolds, the Zn/Co‐MOF functionalized β‐TCP (MOF‐TCP) scaffolds with broad‐spectrum ROS‐scavenging ability are successfully developed. Benefiting from its catalytic active sites and degradation products, Zn/Co‐MOF endows the scaffolds with excellent antioxidative and anti‐inflammatory properties to protect cells from ROS invasion, as well as dual‐bioactivities of simultaneously inducing osteogenic and chondrogenic differentiation in vitro. Furthermore, in vivo results confirm that MOF‐TCP scaffolds accelerate the integrated regeneration of cartilage and subchondral bone in severe osteochondral defects. This study offers a promising strategy for treating defects induced by OA as well as other inflammatory diseases. |
| first_indexed | 2024-04-09T14:16:16Z |
| format | Article |
| id | doaj.art-69713a8dc9c14df6a7ad12c2fa94a33c |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-09T14:16:16Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-69713a8dc9c14df6a7ad12c2fa94a33c2023-05-05T09:24:48ZengWileyAdvanced Science2198-38442023-05-011013n/an/a10.1002/advs.202206875Metal‐Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative Activity for Enhanced Osteochondral RegenerationChaoqin Shu0Chen Qin1Lei Chen2Yufeng Wang3Zhe Shi4Jiangming Yu5Jimin Huang6Chaoqian Zhao7Zhiguang Huan8Chengtie Wu9Min Zhu10Yufang Zhu11State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaDepartment of Orthopaedics Tongren Hospital Shanghai Jiaotong University Shanghai 200336 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaSchool of Materials and Chemistry University of Shanghai for Science and Technology Shanghai 200093 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaAbstract Osteoarthritis (OA) is a degenerative disease that often causes cartilage lesions and even osteochondral damage. Osteochondral defects induced by OA are accompanied by an inflammatory arthrosis microenvironment with overproduced reactive oxygen species (ROS), resulting in the exacerbation of defects and difficulty regenerating osteochondral tissues. Therefore, it is urgently needed to develop osteochondral scaffolds that can not only promote the integrated regeneration of cartilage and subchondral bone, but also possess ROS‐scavenging ability to protect tissues from oxidative stress. Herein, zinc‐cobalt bimetallic organic framework (Zn/Co‐MOF) functionalized bioceramic scaffolds are designed for repairing osteochondral defects under OA environment. By functionalizing Zn/Co‐MOF on the 3D‐printed beta‐tricalcium phosphate (β‐TCP) scaffolds, the Zn/Co‐MOF functionalized β‐TCP (MOF‐TCP) scaffolds with broad‐spectrum ROS‐scavenging ability are successfully developed. Benefiting from its catalytic active sites and degradation products, Zn/Co‐MOF endows the scaffolds with excellent antioxidative and anti‐inflammatory properties to protect cells from ROS invasion, as well as dual‐bioactivities of simultaneously inducing osteogenic and chondrogenic differentiation in vitro. Furthermore, in vivo results confirm that MOF‐TCP scaffolds accelerate the integrated regeneration of cartilage and subchondral bone in severe osteochondral defects. This study offers a promising strategy for treating defects induced by OA as well as other inflammatory diseases.https://doi.org/10.1002/advs.202206875antioxidative stressbioceramic scaffoldsmetal‐organic frameworksosteochondral regeneration |
| spellingShingle | Chaoqin Shu Chen Qin Lei Chen Yufeng Wang Zhe Shi Jiangming Yu Jimin Huang Chaoqian Zhao Zhiguang Huan Chengtie Wu Min Zhu Yufang Zhu Metal‐Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration Advanced Science antioxidative stress bioceramic scaffolds metal‐organic frameworks osteochondral regeneration |
| title | Metal‐Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration |
| title_full | Metal‐Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration |
| title_fullStr | Metal‐Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration |
| title_full_unstemmed | Metal‐Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration |
| title_short | Metal‐Organic Framework Functionalized Bioceramic Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration |
| title_sort | metal organic framework functionalized bioceramic scaffolds with antioxidative activity for enhanced osteochondral regeneration |
| topic | antioxidative stress bioceramic scaffolds metal‐organic frameworks osteochondral regeneration |
| url | https://doi.org/10.1002/advs.202206875 |
| work_keys_str_mv | AT chaoqinshu metalorganicframeworkfunctionalizedbioceramicscaffoldswithantioxidativeactivityforenhancedosteochondralregeneration AT chenqin metalorganicframeworkfunctionalizedbioceramicscaffoldswithantioxidativeactivityforenhancedosteochondralregeneration AT leichen metalorganicframeworkfunctionalizedbioceramicscaffoldswithantioxidativeactivityforenhancedosteochondralregeneration AT yufengwang metalorganicframeworkfunctionalizedbioceramicscaffoldswithantioxidativeactivityforenhancedosteochondralregeneration AT zheshi metalorganicframeworkfunctionalizedbioceramicscaffoldswithantioxidativeactivityforenhancedosteochondralregeneration AT jiangmingyu metalorganicframeworkfunctionalizedbioceramicscaffoldswithantioxidativeactivityforenhancedosteochondralregeneration AT jiminhuang metalorganicframeworkfunctionalizedbioceramicscaffoldswithantioxidativeactivityforenhancedosteochondralregeneration AT chaoqianzhao metalorganicframeworkfunctionalizedbioceramicscaffoldswithantioxidativeactivityforenhancedosteochondralregeneration AT zhiguanghuan metalorganicframeworkfunctionalizedbioceramicscaffoldswithantioxidativeactivityforenhancedosteochondralregeneration AT chengtiewu metalorganicframeworkfunctionalizedbioceramicscaffoldswithantioxidativeactivityforenhancedosteochondralregeneration AT minzhu metalorganicframeworkfunctionalizedbioceramicscaffoldswithantioxidativeactivityforenhancedosteochondralregeneration AT yufangzhu metalorganicframeworkfunctionalizedbioceramicscaffoldswithantioxidativeactivityforenhancedosteochondralregeneration |