Effectiveness of human papillomavirus vaccination in young Japanese women: a retrospective multi-municipality study
In Japan, government support for human papillomavirus (HPV) vaccination began in November 2010. However, the mass media repeatedly reported on severe adverse events. The Japanese Ministry of Health, Labor and Welfare suspended proactive recommendations for HPV vaccines in June 2013. Japan’s HPV vacc...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-04-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2020.1817715 |
| _version_ | 1797677282103394304 |
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| author | Akiko Tozawa-Ono Masaharu Kamada Katsuhiro Teramoto Hitoshi Hareyama Shoji Kodama Tokuzo Kasai Osamu Iwanari Tomoe Koizumi Nobuyoshi Ozawa Mitsuaki Suzuki Katsuyuki Kinoshita |
| author_facet | Akiko Tozawa-Ono Masaharu Kamada Katsuhiro Teramoto Hitoshi Hareyama Shoji Kodama Tokuzo Kasai Osamu Iwanari Tomoe Koizumi Nobuyoshi Ozawa Mitsuaki Suzuki Katsuyuki Kinoshita |
| author_sort | Akiko Tozawa-Ono |
| collection | DOAJ |
| description | In Japan, government support for human papillomavirus (HPV) vaccination began in November 2010. However, the mass media repeatedly reported on severe adverse events. The Japanese Ministry of Health, Labor and Welfare suspended proactive recommendations for HPV vaccines in June 2013. Japan’s HPV vaccination rate dropped from 70% to less than 1% in 2017. We examined cervical cancer screening results in terms of abnormal cytology, histology, and HPV vaccination status among 11,903 women aged 20 to 25 y in the fiscal year 2015. The overall rate of HPV vaccination was 26.1% (3,112/11,903). Regarding cytology, the rate of atypical squamous cells of undetermined significance (ASC-US) or worse was 3.3% (103/3,112) in women who received HPV vaccination (vaccine (+) women) and 5.6% (496/8,791) in women who did not (vaccine (-) women). The rate of high-grade squamous intraepithelial lesion (HSIL) or worse was 0.26% (8/3,112) in vaccine (+) women and 0.81% (72/8,791) in vaccine (-) women. Regarding histology, the rate of cervical intraepithelial neoplasia 1 or worse (CIN1+) was 1.4% (42/3,112) in vaccine (+) women and 2.1% (178/8,791) in vaccine (-) women. The rates of CIN2+ and CIN3+ were similar regardless of vaccination. We found a significantly lower incidence of CIN in vaccine (+) women. These results suggest that the resumption of recommending HPV vaccination as primary prevention for cervical cancer is needed in Japan. |
| first_indexed | 2024-03-11T22:41:51Z |
| format | Article |
| id | doaj.art-69729d0a1fb848a5a95d1bf8f4b3886a |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:41:51Z |
| publishDate | 2021-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-69729d0a1fb848a5a95d1bf8f4b3886a2023-09-22T08:51:51ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-04-0117495095410.1080/21645515.2020.18177151817715Effectiveness of human papillomavirus vaccination in young Japanese women: a retrospective multi-municipality studyAkiko Tozawa-Ono0Masaharu Kamada1Katsuhiro Teramoto2Hitoshi Hareyama3Shoji Kodama4Tokuzo Kasai5Osamu Iwanari6Tomoe Koizumi7Nobuyoshi Ozawa8Mitsuaki Suzuki9Katsuyuki Kinoshita10Toyoko HospitalShikoku Central HospitalYamanashi Koseiren Health Care CenterSapporo Maternity Women’s JR-Tower ClinicNiigata Minami HospitalChiba Foundation for Health Promotion& Disease PreventionShimane Prefectural Central HospitalDokkyo Medical University Saitama Medical Center: KoshigayaOzawa Women’s General ClinicShin-Yurigaoka General HospitalSeijyo Kinoshita HospitalIn Japan, government support for human papillomavirus (HPV) vaccination began in November 2010. However, the mass media repeatedly reported on severe adverse events. The Japanese Ministry of Health, Labor and Welfare suspended proactive recommendations for HPV vaccines in June 2013. Japan’s HPV vaccination rate dropped from 70% to less than 1% in 2017. We examined cervical cancer screening results in terms of abnormal cytology, histology, and HPV vaccination status among 11,903 women aged 20 to 25 y in the fiscal year 2015. The overall rate of HPV vaccination was 26.1% (3,112/11,903). Regarding cytology, the rate of atypical squamous cells of undetermined significance (ASC-US) or worse was 3.3% (103/3,112) in women who received HPV vaccination (vaccine (+) women) and 5.6% (496/8,791) in women who did not (vaccine (-) women). The rate of high-grade squamous intraepithelial lesion (HSIL) or worse was 0.26% (8/3,112) in vaccine (+) women and 0.81% (72/8,791) in vaccine (-) women. Regarding histology, the rate of cervical intraepithelial neoplasia 1 or worse (CIN1+) was 1.4% (42/3,112) in vaccine (+) women and 2.1% (178/8,791) in vaccine (-) women. The rates of CIN2+ and CIN3+ were similar regardless of vaccination. We found a significantly lower incidence of CIN in vaccine (+) women. These results suggest that the resumption of recommending HPV vaccination as primary prevention for cervical cancer is needed in Japan.http://dx.doi.org/10.1080/21645515.2020.1817715cytologycervical intraepithelial neoplasiahuman papillomavirus vaccinationjapan |
| spellingShingle | Akiko Tozawa-Ono Masaharu Kamada Katsuhiro Teramoto Hitoshi Hareyama Shoji Kodama Tokuzo Kasai Osamu Iwanari Tomoe Koizumi Nobuyoshi Ozawa Mitsuaki Suzuki Katsuyuki Kinoshita Effectiveness of human papillomavirus vaccination in young Japanese women: a retrospective multi-municipality study Human Vaccines & Immunotherapeutics cytology cervical intraepithelial neoplasia human papillomavirus vaccination japan |
| title | Effectiveness of human papillomavirus vaccination in young Japanese women: a retrospective multi-municipality study |
| title_full | Effectiveness of human papillomavirus vaccination in young Japanese women: a retrospective multi-municipality study |
| title_fullStr | Effectiveness of human papillomavirus vaccination in young Japanese women: a retrospective multi-municipality study |
| title_full_unstemmed | Effectiveness of human papillomavirus vaccination in young Japanese women: a retrospective multi-municipality study |
| title_short | Effectiveness of human papillomavirus vaccination in young Japanese women: a retrospective multi-municipality study |
| title_sort | effectiveness of human papillomavirus vaccination in young japanese women a retrospective multi municipality study |
| topic | cytology cervical intraepithelial neoplasia human papillomavirus vaccination japan |
| url | http://dx.doi.org/10.1080/21645515.2020.1817715 |
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