RNA Packaging in the <i>Cystovirus</i> Bacteriophages: Dynamic Interactions during Capsid Maturation
The bacteriophage family <i>Cystoviridae</i> consists of a single genus, <i>Cystovirus</i>, that is lipid-containing with three double-stranded RNA (ds-RNA) genome segments. With regard to the segmented dsRNA genome, they resemble the family <i>Reoviridae</i>. The...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/5/2677 |
| _version_ | 1797474925958660096 |
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| author | Paul Gottlieb Aleksandra Alimova |
| author_facet | Paul Gottlieb Aleksandra Alimova |
| author_sort | Paul Gottlieb |
| collection | DOAJ |
| description | The bacteriophage family <i>Cystoviridae</i> consists of a single genus, <i>Cystovirus</i>, that is lipid-containing with three double-stranded RNA (ds-RNA) genome segments. With regard to the segmented dsRNA genome, they resemble the family <i>Reoviridae</i>. Therefore, the <i>Cystoviruses</i> have long served as a simple model for reovirus assembly. This review focuses on important developments in the study of the RNA packaging and replication mechanisms, emphasizing the structural conformations and dynamic changes during maturation of the five proteins required for viral RNA synthesis, P1, P2, P4, P7, and P8. Together these proteins constitute the procapsid/polymerase complex (PC) and nucleocapsid (NC) of the <i>Cystoviruses</i>. During viral assembly and RNA packaging, the five proteins must function in a coordinated fashion as the PC and NC undergo expansion with significant position translation. The review emphasizes this facet of the viral assembly process and speculates on areas suggestive of additional research efforts. |
| first_indexed | 2024-03-09T20:36:56Z |
| format | Article |
| id | doaj.art-697951fedf074b57ade0f158c7f43a79 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:36:56Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-697951fedf074b57ade0f158c7f43a792023-11-23T23:07:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01235267710.3390/ijms23052677RNA Packaging in the <i>Cystovirus</i> Bacteriophages: Dynamic Interactions during Capsid MaturationPaul Gottlieb0Aleksandra Alimova1School of Medicine, The City College of New York, The City University of New York (CUNY), New York, NY 10530, USASchool of Medicine, The City College of New York, The City University of New York (CUNY), New York, NY 10530, USAThe bacteriophage family <i>Cystoviridae</i> consists of a single genus, <i>Cystovirus</i>, that is lipid-containing with three double-stranded RNA (ds-RNA) genome segments. With regard to the segmented dsRNA genome, they resemble the family <i>Reoviridae</i>. Therefore, the <i>Cystoviruses</i> have long served as a simple model for reovirus assembly. This review focuses on important developments in the study of the RNA packaging and replication mechanisms, emphasizing the structural conformations and dynamic changes during maturation of the five proteins required for viral RNA synthesis, P1, P2, P4, P7, and P8. Together these proteins constitute the procapsid/polymerase complex (PC) and nucleocapsid (NC) of the <i>Cystoviruses</i>. During viral assembly and RNA packaging, the five proteins must function in a coordinated fashion as the PC and NC undergo expansion with significant position translation. The review emphasizes this facet of the viral assembly process and speculates on areas suggestive of additional research efforts.https://www.mdpi.com/1422-0067/23/5/2677procapsidnucleocapsidpolymerase complexassemblyreplicationpackaging |
| spellingShingle | Paul Gottlieb Aleksandra Alimova RNA Packaging in the <i>Cystovirus</i> Bacteriophages: Dynamic Interactions during Capsid Maturation International Journal of Molecular Sciences procapsid nucleocapsid polymerase complex assembly replication packaging |
| title | RNA Packaging in the <i>Cystovirus</i> Bacteriophages: Dynamic Interactions during Capsid Maturation |
| title_full | RNA Packaging in the <i>Cystovirus</i> Bacteriophages: Dynamic Interactions during Capsid Maturation |
| title_fullStr | RNA Packaging in the <i>Cystovirus</i> Bacteriophages: Dynamic Interactions during Capsid Maturation |
| title_full_unstemmed | RNA Packaging in the <i>Cystovirus</i> Bacteriophages: Dynamic Interactions during Capsid Maturation |
| title_short | RNA Packaging in the <i>Cystovirus</i> Bacteriophages: Dynamic Interactions during Capsid Maturation |
| title_sort | rna packaging in the i cystovirus i bacteriophages dynamic interactions during capsid maturation |
| topic | procapsid nucleocapsid polymerase complex assembly replication packaging |
| url | https://www.mdpi.com/1422-0067/23/5/2677 |
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