Cancer Risk and Mutational Patterns Following Organ Transplantation
The rapid development of medical technology and widespread application of immunosuppressive drugs have improved the success rate of organ transplantation significantly. However, the use of immunosuppressive agents increases the frequency of malignancy greatly. With the prospect of “precision medicin...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.956334/full |
| _version_ | 1811237082369097728 |
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| author | Yangyang Shen Di Lian Kai Shi Yuefeng Gao Yuefeng Gao Xiaoxiang Hu Kun Yu Qian Zhao Chungang Feng |
| author_facet | Yangyang Shen Di Lian Kai Shi Yuefeng Gao Yuefeng Gao Xiaoxiang Hu Kun Yu Qian Zhao Chungang Feng |
| author_sort | Yangyang Shen |
| collection | DOAJ |
| description | The rapid development of medical technology and widespread application of immunosuppressive drugs have improved the success rate of organ transplantation significantly. However, the use of immunosuppressive agents increases the frequency of malignancy greatly. With the prospect of “precision medicine” for tumors and development of next-generation sequencing technology, more attention has been paid to the application of high-throughput sequencing technology in clinical oncology research, which is mainly applied to the early diagnosis of tumors and analysis of tumor-related genes. All generations of cancers carry somatic mutations, meanwhile, significant differences were observed in mutational signatures across tumors. Systematic sequencing of cancer genomes from patients after organ transplantation can reveal DNA damage and repair processes in exposed cancer cells and their precursors. In this review, we summarize the application of high-throughput sequencing and organoids in the field of organ transplantation, the mutational patterns of cancer genomes, and propose a new research strategy for understanding the mechanism of cancer following organ transplantation. |
| first_indexed | 2024-04-12T12:20:00Z |
| format | Article |
| id | doaj.art-697f23d4cded4fbf9c22d18d0626bb2e |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T12:20:00Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-697f23d4cded4fbf9c22d18d0626bb2e2022-12-22T03:33:19ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-06-011010.3389/fcell.2022.956334956334Cancer Risk and Mutational Patterns Following Organ TransplantationYangyang Shen0Di Lian1Kai Shi2Yuefeng Gao3Yuefeng Gao4Xiaoxiang Hu5Kun Yu6Qian Zhao7Chungang Feng8College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, ChinaState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, ChinaCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, ChinaCollege of Applied Engineering, Henan University of Science and Technology, Sanmenxia, ChinaSanmenxia Polytechnic, Sanmenxia, ChinaState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, ChinaCollege of Animal Science and Technology, China Agricultural University, Beijing, ChinaCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, ChinaCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, ChinaThe rapid development of medical technology and widespread application of immunosuppressive drugs have improved the success rate of organ transplantation significantly. However, the use of immunosuppressive agents increases the frequency of malignancy greatly. With the prospect of “precision medicine” for tumors and development of next-generation sequencing technology, more attention has been paid to the application of high-throughput sequencing technology in clinical oncology research, which is mainly applied to the early diagnosis of tumors and analysis of tumor-related genes. All generations of cancers carry somatic mutations, meanwhile, significant differences were observed in mutational signatures across tumors. Systematic sequencing of cancer genomes from patients after organ transplantation can reveal DNA damage and repair processes in exposed cancer cells and their precursors. In this review, we summarize the application of high-throughput sequencing and organoids in the field of organ transplantation, the mutational patterns of cancer genomes, and propose a new research strategy for understanding the mechanism of cancer following organ transplantation.https://www.frontiersin.org/articles/10.3389/fcell.2022.956334/fullorgan transplantationcancernext-generation sequencing technologymutational patternsorganoids |
| spellingShingle | Yangyang Shen Di Lian Kai Shi Yuefeng Gao Yuefeng Gao Xiaoxiang Hu Kun Yu Qian Zhao Chungang Feng Cancer Risk and Mutational Patterns Following Organ Transplantation Frontiers in Cell and Developmental Biology organ transplantation cancer next-generation sequencing technology mutational patterns organoids |
| title | Cancer Risk and Mutational Patterns Following Organ Transplantation |
| title_full | Cancer Risk and Mutational Patterns Following Organ Transplantation |
| title_fullStr | Cancer Risk and Mutational Patterns Following Organ Transplantation |
| title_full_unstemmed | Cancer Risk and Mutational Patterns Following Organ Transplantation |
| title_short | Cancer Risk and Mutational Patterns Following Organ Transplantation |
| title_sort | cancer risk and mutational patterns following organ transplantation |
| topic | organ transplantation cancer next-generation sequencing technology mutational patterns organoids |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.956334/full |
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