Divergent properties and independent regulation of striatal dopamine and GABA co-transmission
Summary: Substantia nigra pars compacta (SNc) dopamine neurons play a key role in regulating the activity of striatal circuits within the basal ganglia. In addition to dopamine, these neurons release several other transmitters, including the major inhibitory neurotransmitter γ-aminobutyric acid (GAB...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124722005940 |
| _version_ | 1818244971999789056 |
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| author | Sarah M. Zych Christopher P. Ford |
| author_facet | Sarah M. Zych Christopher P. Ford |
| author_sort | Sarah M. Zych |
| collection | DOAJ |
| description | Summary: Substantia nigra pars compacta (SNc) dopamine neurons play a key role in regulating the activity of striatal circuits within the basal ganglia. In addition to dopamine, these neurons release several other transmitters, including the major inhibitory neurotransmitter γ-aminobutyric acid (GABA). Both dopamine and GABA are loaded into SNc synaptic vesicles by the vesicular monoamine transporter 2 (VMAT2), and co-release of GABA provides strong inhibition to the striatum by directly inhibiting striatal medium spiny projection neurons (MSNs) through activation of GABAA receptors. Here, we found that despite both dopamine and GABA being co-packaged by VMAT2, the properties of transmission, including Ca2+ sensitivity, release probability, and requirement of active zone scaffolding proteins, differ between the two transmitters. Moreover, the extent by which presynaptic neuromodulators inhibit co-transmission also varied. Differences in modulation and the mechanisms controlling release allow for independent regulation of dopamine and GABA signals despite both being loaded via similar mechanisms. |
| first_indexed | 2024-12-12T14:25:30Z |
| format | Article |
| id | doaj.art-697fb1a9ffbb4a3b92c79fdb1e5cf23c |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-12T14:25:30Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-697fb1a9ffbb4a3b92c79fdb1e5cf23c2022-12-22T00:21:41ZengElsevierCell Reports2211-12472022-05-01397110823Divergent properties and independent regulation of striatal dopamine and GABA co-transmissionSarah M. Zych0Christopher P. Ford1Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 E 19th Ave, Aurora, CO 80045, USADepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, 12800 E 19th Ave, Aurora, CO 80045, USA; Corresponding authorSummary: Substantia nigra pars compacta (SNc) dopamine neurons play a key role in regulating the activity of striatal circuits within the basal ganglia. In addition to dopamine, these neurons release several other transmitters, including the major inhibitory neurotransmitter γ-aminobutyric acid (GABA). Both dopamine and GABA are loaded into SNc synaptic vesicles by the vesicular monoamine transporter 2 (VMAT2), and co-release of GABA provides strong inhibition to the striatum by directly inhibiting striatal medium spiny projection neurons (MSNs) through activation of GABAA receptors. Here, we found that despite both dopamine and GABA being co-packaged by VMAT2, the properties of transmission, including Ca2+ sensitivity, release probability, and requirement of active zone scaffolding proteins, differ between the two transmitters. Moreover, the extent by which presynaptic neuromodulators inhibit co-transmission also varied. Differences in modulation and the mechanisms controlling release allow for independent regulation of dopamine and GABA signals despite both being loaded via similar mechanisms.http://www.sciencedirect.com/science/article/pii/S2211124722005940CP: Neuroscience |
| spellingShingle | Sarah M. Zych Christopher P. Ford Divergent properties and independent regulation of striatal dopamine and GABA co-transmission Cell Reports CP: Neuroscience |
| title | Divergent properties and independent regulation of striatal dopamine and GABA co-transmission |
| title_full | Divergent properties and independent regulation of striatal dopamine and GABA co-transmission |
| title_fullStr | Divergent properties and independent regulation of striatal dopamine and GABA co-transmission |
| title_full_unstemmed | Divergent properties and independent regulation of striatal dopamine and GABA co-transmission |
| title_short | Divergent properties and independent regulation of striatal dopamine and GABA co-transmission |
| title_sort | divergent properties and independent regulation of striatal dopamine and gaba co transmission |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124722005940 |
| work_keys_str_mv | AT sarahmzych divergentpropertiesandindependentregulationofstriataldopamineandgabacotransmission AT christopherpford divergentpropertiesandindependentregulationofstriataldopamineandgabacotransmission |