Nanopolyphenols: Perspective on oxidative stress-induced diseases
Recently nanopolyphenols are gaining widespread interest in the drug discovery domain. Nanonization of polyphenols has greatly affected the therapeutic index owing to improvement in pharmacokinetic and biopharmaceutical obstacles linked with the use of natural polyphenols. They have been looking at...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | MGM Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.mgmjms.com/article.asp?issn=2347-7946;year=2022;volume=9;issue=3;spage=419;epage=430;aulast=Rathod |
| _version_ | 1797995510857990144 |
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| author | Priyanka Rathod Raman P Yadav |
| author_facet | Priyanka Rathod Raman P Yadav |
| author_sort | Priyanka Rathod |
| collection | DOAJ |
| description | Recently nanopolyphenols are gaining widespread interest in the drug discovery domain. Nanonization of polyphenols has greatly affected the therapeutic index owing to improvement in pharmacokinetic and biopharmaceutical obstacles linked with the use of natural polyphenols. They have been looking at an emerging paradigm for an array of disease symptoms. In this article, we have explored the therapeutic potential of nanopolyphenols in oxidative stress-induced diseases such as neurodegeneration, cancer, obesity, and diabetes. This article will present the current state of the art of various nanopolyphenols targeting oxidative stress-induced diseases. The advanced fabrication strategies presented for polyphenols including nanocrystal, mesoporous silica nanoparticles, nanoparticles, nanoliposome, gold nanoparticle, and nanosuspension are discussed. The information presented in light of recent in vitro, in vivo, and clinical evidence for nanoformulation and delivery of polyphenols may show a new dimension to future research in the realm of herbal therapy for oxidative stress-induced diseases. Significant information on the molecular mechanisms underlying linkages of oxidative stress with neurodegenerative diseases, cancer, obesity, and diabetes is discussed. Valuable information on dietary polyphenols in these diseases and their clinical data is presented. Based on different experimental evidence, the review findings support phenomenal therapeutic strategies for nanopolyphenolic fabrication with extended benefits and a condensed time frame. The status of clinical trials conducted on nanopolyphenols is presented. Although clinical trials conducted on nanopolyphenols for mentioned diseases are few, we have tried to present as much available clinical data in this article. |
| first_indexed | 2024-04-11T10:02:54Z |
| format | Article |
| id | doaj.art-6980dc4240f448538e7a5fb23a13ae91 |
| institution | Directory Open Access Journal |
| issn | 2347-7946 2347-7962 |
| language | English |
| last_indexed | 2024-04-11T10:02:54Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | MGM Journal of Medical Sciences |
| spelling | doaj.art-6980dc4240f448538e7a5fb23a13ae912022-12-22T04:30:20ZengWolters Kluwer Medknow PublicationsMGM Journal of Medical Sciences2347-79462347-79622022-01-019341943010.4103/mgmj.mgmj_100_22Nanopolyphenols: Perspective on oxidative stress-induced diseasesPriyanka RathodRaman P YadavRecently nanopolyphenols are gaining widespread interest in the drug discovery domain. Nanonization of polyphenols has greatly affected the therapeutic index owing to improvement in pharmacokinetic and biopharmaceutical obstacles linked with the use of natural polyphenols. They have been looking at an emerging paradigm for an array of disease symptoms. In this article, we have explored the therapeutic potential of nanopolyphenols in oxidative stress-induced diseases such as neurodegeneration, cancer, obesity, and diabetes. This article will present the current state of the art of various nanopolyphenols targeting oxidative stress-induced diseases. The advanced fabrication strategies presented for polyphenols including nanocrystal, mesoporous silica nanoparticles, nanoparticles, nanoliposome, gold nanoparticle, and nanosuspension are discussed. The information presented in light of recent in vitro, in vivo, and clinical evidence for nanoformulation and delivery of polyphenols may show a new dimension to future research in the realm of herbal therapy for oxidative stress-induced diseases. Significant information on the molecular mechanisms underlying linkages of oxidative stress with neurodegenerative diseases, cancer, obesity, and diabetes is discussed. Valuable information on dietary polyphenols in these diseases and their clinical data is presented. Based on different experimental evidence, the review findings support phenomenal therapeutic strategies for nanopolyphenolic fabrication with extended benefits and a condensed time frame. The status of clinical trials conducted on nanopolyphenols is presented. Although clinical trials conducted on nanopolyphenols for mentioned diseases are few, we have tried to present as much available clinical data in this article.http://www.mgmjms.com/article.asp?issn=2347-7946;year=2022;volume=9;issue=3;spage=419;epage=430;aulast=Rathodantioxidantcancerdiabetesnanopolyphenolsneurodegenerationobesityoxidativestress |
| spellingShingle | Priyanka Rathod Raman P Yadav Nanopolyphenols: Perspective on oxidative stress-induced diseases MGM Journal of Medical Sciences antioxidant cancer diabetes nanopolyphenols neurodegeneration obesity oxidative stress |
| title | Nanopolyphenols: Perspective on oxidative stress-induced diseases |
| title_full | Nanopolyphenols: Perspective on oxidative stress-induced diseases |
| title_fullStr | Nanopolyphenols: Perspective on oxidative stress-induced diseases |
| title_full_unstemmed | Nanopolyphenols: Perspective on oxidative stress-induced diseases |
| title_short | Nanopolyphenols: Perspective on oxidative stress-induced diseases |
| title_sort | nanopolyphenols perspective on oxidative stress induced diseases |
| topic | antioxidant cancer diabetes nanopolyphenols neurodegeneration obesity oxidative stress |
| url | http://www.mgmjms.com/article.asp?issn=2347-7946;year=2022;volume=9;issue=3;spage=419;epage=430;aulast=Rathod |
| work_keys_str_mv | AT priyankarathod nanopolyphenolsperspectiveonoxidativestressinduceddiseases AT ramanpyadav nanopolyphenolsperspectiveonoxidativestressinduceddiseases |