NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer
IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/9/1278 |
| _version_ | 1797520115866009600 |
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| author | Lluís Espinosa Laura Marruecos |
| author_facet | Lluís Espinosa Laura Marruecos |
| author_sort | Lluís Espinosa |
| collection | DOAJ |
| description | IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein. |
| first_indexed | 2024-03-10T07:52:16Z |
| format | Article |
| id | doaj.art-69827e45c37147b49e2a4528960ac68f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T07:52:16Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-69827e45c37147b49e2a4528960ac68f2023-11-22T12:09:42ZengMDPI AGBiomedicines2227-90592021-09-0199127810.3390/biomedicines9091278NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and CancerLluís Espinosa0Laura Marruecos1Cancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del Mar, Doctor Aiguader 88, 08003 Barcelona, SpainCancer Research Program, Institut Mar d’Investigacions Mèdiques, CIBERONC, Hospital del Mar, Doctor Aiguader 88, 08003 Barcelona, SpainIκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein.https://www.mdpi.com/2227-9059/9/9/1278IκBαSUMOylationNF-κBpolycomb repression complex (PRC) 2cancer |
| spellingShingle | Lluís Espinosa Laura Marruecos NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer Biomedicines IκBα SUMOylation NF-κB polycomb repression complex (PRC) 2 cancer |
| title | NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer |
| title_full | NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer |
| title_fullStr | NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer |
| title_full_unstemmed | NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer |
| title_short | NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer |
| title_sort | nf κb dependent and independent moonlighting iκbα functions in differentiation and cancer |
| topic | IκBα SUMOylation NF-κB polycomb repression complex (PRC) 2 cancer |
| url | https://www.mdpi.com/2227-9059/9/9/1278 |
| work_keys_str_mv | AT lluisespinosa nfkbdependentandindependentmoonlightingikbafunctionsindifferentiationandcancer AT lauramarruecos nfkbdependentandindependentmoonlightingikbafunctionsindifferentiationandcancer |