NSAID-GASTRODUODENOPATHIES IN PATIENTS WITH OSTEOARTHRITIS: PECULIARITIES OF DIAGNOSTICS, PREVENTION AND TREATMENT
Objective. To improve both prophylaxis and treatment of NSA ID-associated gastroduodenopathies in osteoar- thritic patients. Material and methods. The study included 155 osieoarthritic pts., NSAID-therapy included ibuprofen, meloxi- cam or different forms of diclofenac. Endoscopy before investigatio...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IMA PRESS LLC
2002-06-01
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| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1123 |
| _version_ | 1797863058380423168 |
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| author | A. S. Svintzitzky O G Puzcmova |
| author_facet | A. S. Svintzitzky O G Puzcmova |
| author_sort | A. S. Svintzitzky |
| collection | DOAJ |
| description | Objective. To improve both prophylaxis and treatment of NSA ID-associated gastroduodenopathies in osteoar- thritic patients. Material and methods. The study included 155 osieoarthritic pts., NSAID-therapy included ibuprofen, meloxi- cam or different forms of diclofenac. Endoscopy before investigation, on the 4-5"' day and on the 3 ,J week (with gastrobiopsy in 37) was performed, as well as basal intragastric pH study (in 57), basal cortisolemia level - immunoassay (in 124). Diagnosis of Helicobacter pylori (in 88) by ELISA and biochemical methods. Results. Taking into account both NSAID-therapy duration and its methods used, the risk-factors presented, patients’ Helicobacter pylori-status and their adrenal glands’ cortisol-productive function, it has been described the frequency of the revealed erosive-and-ulcerous lesions, as well as their clinical and endoscopic peculiarities. The efficacy of ulcers monotherapy with misoprostol has been evaluated. Conclusion. It is expedient first local, then prostaglandin-dependent gastroprotection while taking NSAID, both in Hp-negative and positive pts. Concomitant Helicobacter pylori-infection does not worsen 3-week NSAID- therapy gastric tolerability, but hypercortisolemia does so. Misoprostol proved to be expedient in ulserous gas- troduodcnopathy . |
| first_indexed | 2024-04-09T22:29:29Z |
| format | Article |
| id | doaj.art-6983a4b9c01b4cdc8fd076b0b6599252 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:29:29Z |
| publishDate | 2002-06-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-6983a4b9c01b4cdc8fd076b0b65992522023-03-22T13:45:38ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922002-06-01403263110.14412/1995-4484-2002-12131063NSAID-GASTRODUODENOPATHIES IN PATIENTS WITH OSTEOARTHRITIS: PECULIARITIES OF DIAGNOSTICS, PREVENTION AND TREATMENTA. S. SvintzitzkyO G PuzcmovaObjective. To improve both prophylaxis and treatment of NSA ID-associated gastroduodenopathies in osteoar- thritic patients. Material and methods. The study included 155 osieoarthritic pts., NSAID-therapy included ibuprofen, meloxi- cam or different forms of diclofenac. Endoscopy before investigation, on the 4-5"' day and on the 3 ,J week (with gastrobiopsy in 37) was performed, as well as basal intragastric pH study (in 57), basal cortisolemia level - immunoassay (in 124). Diagnosis of Helicobacter pylori (in 88) by ELISA and biochemical methods. Results. Taking into account both NSAID-therapy duration and its methods used, the risk-factors presented, patients’ Helicobacter pylori-status and their adrenal glands’ cortisol-productive function, it has been described the frequency of the revealed erosive-and-ulcerous lesions, as well as their clinical and endoscopic peculiarities. The efficacy of ulcers monotherapy with misoprostol has been evaluated. Conclusion. It is expedient first local, then prostaglandin-dependent gastroprotection while taking NSAID, both in Hp-negative and positive pts. Concomitant Helicobacter pylori-infection does not worsen 3-week NSAID- therapy gastric tolerability, but hypercortisolemia does so. Misoprostol proved to be expedient in ulserous gas- troduodcnopathy .https://rsp.mediar-press.net/rsp/article/view/1123helicobacter pvloriosteoarthritisnonsteroidal anti-inflammatory druns (nsaids)gastroduodenopathvhelicobacter pyloricortisol |
| spellingShingle | A. S. Svintzitzky O G Puzcmova NSAID-GASTRODUODENOPATHIES IN PATIENTS WITH OSTEOARTHRITIS: PECULIARITIES OF DIAGNOSTICS, PREVENTION AND TREATMENT Научно-практическая ревматология helicobacter pvlori osteoarthritis nonsteroidal anti-inflammatory druns (nsaids) gastroduodenopathv helicobacter pylori cortisol |
| title | NSAID-GASTRODUODENOPATHIES IN PATIENTS WITH OSTEOARTHRITIS: PECULIARITIES OF DIAGNOSTICS, PREVENTION AND TREATMENT |
| title_full | NSAID-GASTRODUODENOPATHIES IN PATIENTS WITH OSTEOARTHRITIS: PECULIARITIES OF DIAGNOSTICS, PREVENTION AND TREATMENT |
| title_fullStr | NSAID-GASTRODUODENOPATHIES IN PATIENTS WITH OSTEOARTHRITIS: PECULIARITIES OF DIAGNOSTICS, PREVENTION AND TREATMENT |
| title_full_unstemmed | NSAID-GASTRODUODENOPATHIES IN PATIENTS WITH OSTEOARTHRITIS: PECULIARITIES OF DIAGNOSTICS, PREVENTION AND TREATMENT |
| title_short | NSAID-GASTRODUODENOPATHIES IN PATIENTS WITH OSTEOARTHRITIS: PECULIARITIES OF DIAGNOSTICS, PREVENTION AND TREATMENT |
| title_sort | nsaid gastroduodenopathies in patients with osteoarthritis peculiarities of diagnostics prevention and treatment |
| topic | helicobacter pvlori osteoarthritis nonsteroidal anti-inflammatory druns (nsaids) gastroduodenopathv helicobacter pylori cortisol |
| url | https://rsp.mediar-press.net/rsp/article/view/1123 |
| work_keys_str_mv | AT assvintzitzky nsaidgastroduodenopathiesinpatientswithosteoarthritispeculiaritiesofdiagnosticspreventionandtreatment AT ogpuzcmova nsaidgastroduodenopathiesinpatientswithosteoarthritispeculiaritiesofdiagnosticspreventionandtreatment |