The Adipocyte–Macrophage Relationship in Cancer: A Potential Target for Antioxidant Therapy
Obesity has emerged as a major public health concern with a staggering 39% worldwide prevalence as of 2021. Given the magnitude of the problem and considering its association with chronic low-grade systemic inflammation, it does not come as a surprise that obesity is now considered one of the major...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/1/126 |
| _version_ | 1797446826238935040 |
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| author | Sofía Sanhueza Layla Simón Mariana Cifuentes Andrew F. G. Quest |
| author_facet | Sofía Sanhueza Layla Simón Mariana Cifuentes Andrew F. G. Quest |
| author_sort | Sofía Sanhueza |
| collection | DOAJ |
| description | Obesity has emerged as a major public health concern with a staggering 39% worldwide prevalence as of 2021. Given the magnitude of the problem and considering its association with chronic low-grade systemic inflammation, it does not come as a surprise that obesity is now considered one of the major risk factors for the development of several chronic diseases, such as diabetes, cardiovascular problems, and cancer. Adipose tissue dysfunction in obesity has taken center stage in understanding how changes in its components, particularly adipocytes and macrophages, participate in such processes. In this review, we will initially focus on how changes in adipose tissue upon excess fat accumulation generate endocrine signals that promote cancer development. Moreover, the tumor microenvironment or stroma, which is also critical in cancer development, contains macrophages and adipocytes, which, in reciprocal paracrine communication with cancer cells, generate relevant signals. We will discuss how paracrine signaling in the tumor microenvironment between cancer cells, macrophages, and adipocytes favors cancer development and progression. Finally, as reactive oxygen species participate in many of these signaling pathways, we will summarize the information available on how antioxidants can limit the effects of endocrine and paracrine signaling due to dysfunctional adipose tissue components in obesity. |
| first_indexed | 2024-03-09T13:46:08Z |
| format | Article |
| id | doaj.art-6984547e228a4b5981a7ed843e5ed762 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T13:46:08Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-6984547e228a4b5981a7ed843e5ed7622023-11-30T20:58:41ZengMDPI AGAntioxidants2076-39212023-01-0112112610.3390/antiox12010126The Adipocyte–Macrophage Relationship in Cancer: A Potential Target for Antioxidant TherapySofía Sanhueza0Layla Simón1Mariana Cifuentes2Andrew F. G. Quest3Cellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380492, ChileCellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380492, ChileAdvanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, University of Chile, Santiago 8380492, ChileCellular Communication Laboratory, Center for Studies on Exercise, Metabolism and Cancer (CEMC), Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago 8380492, ChileObesity has emerged as a major public health concern with a staggering 39% worldwide prevalence as of 2021. Given the magnitude of the problem and considering its association with chronic low-grade systemic inflammation, it does not come as a surprise that obesity is now considered one of the major risk factors for the development of several chronic diseases, such as diabetes, cardiovascular problems, and cancer. Adipose tissue dysfunction in obesity has taken center stage in understanding how changes in its components, particularly adipocytes and macrophages, participate in such processes. In this review, we will initially focus on how changes in adipose tissue upon excess fat accumulation generate endocrine signals that promote cancer development. Moreover, the tumor microenvironment or stroma, which is also critical in cancer development, contains macrophages and adipocytes, which, in reciprocal paracrine communication with cancer cells, generate relevant signals. We will discuss how paracrine signaling in the tumor microenvironment between cancer cells, macrophages, and adipocytes favors cancer development and progression. Finally, as reactive oxygen species participate in many of these signaling pathways, we will summarize the information available on how antioxidants can limit the effects of endocrine and paracrine signaling due to dysfunctional adipose tissue components in obesity.https://www.mdpi.com/2076-3921/12/1/126adipose tissueobesityinflammationantioxidantsendocrine signalingcancer cells |
| spellingShingle | Sofía Sanhueza Layla Simón Mariana Cifuentes Andrew F. G. Quest The Adipocyte–Macrophage Relationship in Cancer: A Potential Target for Antioxidant Therapy Antioxidants adipose tissue obesity inflammation antioxidants endocrine signaling cancer cells |
| title | The Adipocyte–Macrophage Relationship in Cancer: A Potential Target for Antioxidant Therapy |
| title_full | The Adipocyte–Macrophage Relationship in Cancer: A Potential Target for Antioxidant Therapy |
| title_fullStr | The Adipocyte–Macrophage Relationship in Cancer: A Potential Target for Antioxidant Therapy |
| title_full_unstemmed | The Adipocyte–Macrophage Relationship in Cancer: A Potential Target for Antioxidant Therapy |
| title_short | The Adipocyte–Macrophage Relationship in Cancer: A Potential Target for Antioxidant Therapy |
| title_sort | adipocyte macrophage relationship in cancer a potential target for antioxidant therapy |
| topic | adipose tissue obesity inflammation antioxidants endocrine signaling cancer cells |
| url | https://www.mdpi.com/2076-3921/12/1/126 |
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