Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives
Extracellular vesicles (EVs) are vesicle-like substances released by eukaryotic cells. Based on their origin and size, EVs are mainly divided into exosomes, microvesicles and apoptotic bodies, and they are secreted by eukaryotic cells under physiological and pathological conditions. EVs are enriched...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2021-03-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304219301175 |
| _version_ | 1797726691126149120 |
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| author | Qian Yuan Xiao-dong Li Si-miao Zhang Hong-wei Wang Yun-liang Wang |
| author_facet | Qian Yuan Xiao-dong Li Si-miao Zhang Hong-wei Wang Yun-liang Wang |
| author_sort | Qian Yuan |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are vesicle-like substances released by eukaryotic cells. Based on their origin and size, EVs are mainly divided into exosomes, microvesicles and apoptotic bodies, and they are secreted by eukaryotic cells under physiological and pathological conditions. EVs are enriched with nucleic acids, proteins and other factors. EVs can regulate the function of adjacent and distant cells, and they are even involved in the pathogenesis of diseases. They contain proteins associated with the pathogenesis of neurodegenerative diseases (NDs), such as the α-synuclein (α-syn) and tau proteins, which suggest potential roles for EVs as biomarkers and carriers of drugs and other therapeutic molecules that can cross the blood–brain barrier to treat NDs. In this review, we summarized the function of EVs in the pathogenesis of different NDs and related advances in EVs as diagnostic biomarkers and treatments for diseases. |
| first_indexed | 2024-03-12T10:49:31Z |
| format | Article |
| id | doaj.art-6987dfff0f8247b1a83b5b6b19d08b28 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T10:49:31Z |
| publishDate | 2021-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-6987dfff0f8247b1a83b5b6b19d08b282023-09-02T07:12:31ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422021-03-0182124132Extracellular vesicles in neurodegenerative diseases: Insights and new perspectivesQian Yuan0Xiao-dong Li1Si-miao Zhang2Hong-wei Wang3Yun-liang Wang4Department of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450014, PR ChinaDepartment of Neurology, Zhengzhou Central Hospital, Zhengzhou, Henan Province, 450014, PR ChinaDepartment of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450014, PR ChinaDepartment of Medicine, The University of Chicago, IL, 60637, USADepartment of Neurology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450014, PR China; Department of Neurology, The 960th Hospital of Chinese PLA, Zibo, Shandong Province, 255300, PR China; Corresponding author.Extracellular vesicles (EVs) are vesicle-like substances released by eukaryotic cells. Based on their origin and size, EVs are mainly divided into exosomes, microvesicles and apoptotic bodies, and they are secreted by eukaryotic cells under physiological and pathological conditions. EVs are enriched with nucleic acids, proteins and other factors. EVs can regulate the function of adjacent and distant cells, and they are even involved in the pathogenesis of diseases. They contain proteins associated with the pathogenesis of neurodegenerative diseases (NDs), such as the α-synuclein (α-syn) and tau proteins, which suggest potential roles for EVs as biomarkers and carriers of drugs and other therapeutic molecules that can cross the blood–brain barrier to treat NDs. In this review, we summarized the function of EVs in the pathogenesis of different NDs and related advances in EVs as diagnostic biomarkers and treatments for diseases.http://www.sciencedirect.com/science/article/pii/S2352304219301175BiomarkerExosomesExtracellular vesiclesNeurodegenerative diseases |
| spellingShingle | Qian Yuan Xiao-dong Li Si-miao Zhang Hong-wei Wang Yun-liang Wang Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives Genes and Diseases Biomarker Exosomes Extracellular vesicles Neurodegenerative diseases |
| title | Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives |
| title_full | Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives |
| title_fullStr | Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives |
| title_full_unstemmed | Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives |
| title_short | Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives |
| title_sort | extracellular vesicles in neurodegenerative diseases insights and new perspectives |
| topic | Biomarker Exosomes Extracellular vesicles Neurodegenerative diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2352304219301175 |
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