Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects
<p>Abstract</p> <p>Comparative genomics has become a real tantalizing challenge in the postgenomic era. This fact has been mostly magnified by the plethora of new genomes becoming available in a daily bases. The overwhelming list of new genomes to compare has pushed the field of bi...
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Format: | Article |
Language: | English |
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BMC
2009-01-01
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Series: | Biological Procedures Online |
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Online Access: | http://www.biologicalproceduresonline.com/content/11/1/52 |
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author | Commins Jennifer Toft Christina Fares Mario |
author_facet | Commins Jennifer Toft Christina Fares Mario |
author_sort | Commins Jennifer |
collection | DOAJ |
description | <p>Abstract</p> <p>Comparative genomics has become a real tantalizing challenge in the postgenomic era. This fact has been mostly magnified by the plethora of new genomes becoming available in a daily bases. The overwhelming list of new genomes to compare has pushed the field of bioinformatics and computational biology forward toward the design and development of methods capable of identifying patterns in a sea of swamping data noise. Despite many advances made in such endeavor, the ever-lasting annoying exceptions to the general patterns remain to pose difficulties in generalizing methods for comparative genomics. In this review, we discuss the different tools devised to undertake the challenge of comparative genomics and some of the exceptions that compromise the generality of such methods. We focus on endosymbiotic bacteria of insects because of their genomic dynamics peculiarities when compared to free-living organisms.</p> |
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id | doaj.art-69884ad0c58a4cce965f8c59253dd29d |
institution | Directory Open Access Journal |
issn | 1480-9222 |
language | English |
last_indexed | 2024-12-17T04:47:42Z |
publishDate | 2009-01-01 |
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series | Biological Procedures Online |
spelling | doaj.art-69884ad0c58a4cce965f8c59253dd29d2022-12-21T22:03:01ZengBMCBiological Procedures Online1480-92222009-01-011115278Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of InsectsCommins JenniferToft ChristinaFares Mario<p>Abstract</p> <p>Comparative genomics has become a real tantalizing challenge in the postgenomic era. This fact has been mostly magnified by the plethora of new genomes becoming available in a daily bases. The overwhelming list of new genomes to compare has pushed the field of bioinformatics and computational biology forward toward the design and development of methods capable of identifying patterns in a sea of swamping data noise. Despite many advances made in such endeavor, the ever-lasting annoying exceptions to the general patterns remain to pose difficulties in generalizing methods for comparative genomics. In this review, we discuss the different tools devised to undertake the challenge of comparative genomics and some of the exceptions that compromise the generality of such methods. We focus on endosymbiotic bacteria of insects because of their genomic dynamics peculiarities when compared to free-living organisms.</p>http://www.biologicalproceduresonline.com/content/11/1/52Comparative GenomicsOrthologs searchBLASTFunctional CategoriesGenomics Dynamics |
spellingShingle | Commins Jennifer Toft Christina Fares Mario Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects Biological Procedures Online Comparative Genomics Orthologs search BLAST Functional Categories Genomics Dynamics |
title | Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects |
title_full | Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects |
title_fullStr | Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects |
title_full_unstemmed | Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects |
title_short | Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects |
title_sort | computational biology methods and their application to the comparative genomics of endocellular symbiotic bacteria of insects |
topic | Comparative Genomics Orthologs search BLAST Functional Categories Genomics Dynamics |
url | http://www.biologicalproceduresonline.com/content/11/1/52 |
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