Abnormal Default Mode Network Homogeneity in Treatment-Naive Patients With First-Episode Depression
Background and Objective: The default mode network (DMN) may be an important component involved in the broad-scale cognitive problems seen in patients with first-episode treatment-naive depression. Nevertheless, information is scarce regarding the changes in network homogeneity (NH) found in the DMN...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-12-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00697/full |
| _version_ | 1823990307417489408 |
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| author | Yujun Gao Menglin Wang RenQiang Yu Yaping Li Ying Yang Xiangxiang Cui Jinou Zheng |
| author_facet | Yujun Gao Menglin Wang RenQiang Yu Yaping Li Ying Yang Xiangxiang Cui Jinou Zheng |
| author_sort | Yujun Gao |
| collection | DOAJ |
| description | Background and Objective: The default mode network (DMN) may be an important component involved in the broad-scale cognitive problems seen in patients with first-episode treatment-naive depression. Nevertheless, information is scarce regarding the changes in network homogeneity (NH) found in the DMN of these patients. Therefore, in this study, we explored the NH of the DMN in patients with first-episode treatment-naive depression.Methods: The study included 66 patients and 74 control participants matched by age, gender, educational level and health status who underwent resting-state functional magnetic resonance imaging (rs-fMRI) and the attentional network test (ANT). To assess data, the study utilizes NH and independent component analysis (ICA). Additionally, Spearman's rank correlation analysis is performed among significantly abnormal NH in depression patients and clinical measurements and executive control reaction time (ECRT).Results: In comparison with the control group, patients with first-episode treatment-naive depression showed lower NH in the bilateral angular gyrus (AG), as well as increased NH in the bilateral precuneus (PCu) and posterior cingulate cortex (PCC). Likewise, patients with first-episode treatment-naive depression had longer ECRT. No significant relation was found between abnormal NH values and the measured clinical variables.Conclusions: Our results suggest patients with first-episode treatment-naive depression have abnormal NH values in the DMN. This highlights the significance of DMN in the pathophysiology of cognitive problems in depression. Our study also found alterations in executive functions in patients with first-episode treatment-naive depression. |
| first_indexed | 2024-12-18T15:37:47Z |
| format | Article |
| id | doaj.art-6989d17a3684459b9aedd74137ac3395 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-18T15:37:47Z |
| publishDate | 2018-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-6989d17a3684459b9aedd74137ac33952022-12-21T21:02:56ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402018-12-01910.3389/fpsyt.2018.00697405390Abnormal Default Mode Network Homogeneity in Treatment-Naive Patients With First-Episode DepressionYujun Gao0Menglin Wang1RenQiang Yu2Yaping Li3Ying Yang4Xiangxiang Cui5Jinou Zheng6Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaDepartment of Otorhinolaryngology and Head and Neck Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaDepartment of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaThe First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaDepartment of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaDepartment of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaBackground and Objective: The default mode network (DMN) may be an important component involved in the broad-scale cognitive problems seen in patients with first-episode treatment-naive depression. Nevertheless, information is scarce regarding the changes in network homogeneity (NH) found in the DMN of these patients. Therefore, in this study, we explored the NH of the DMN in patients with first-episode treatment-naive depression.Methods: The study included 66 patients and 74 control participants matched by age, gender, educational level and health status who underwent resting-state functional magnetic resonance imaging (rs-fMRI) and the attentional network test (ANT). To assess data, the study utilizes NH and independent component analysis (ICA). Additionally, Spearman's rank correlation analysis is performed among significantly abnormal NH in depression patients and clinical measurements and executive control reaction time (ECRT).Results: In comparison with the control group, patients with first-episode treatment-naive depression showed lower NH in the bilateral angular gyrus (AG), as well as increased NH in the bilateral precuneus (PCu) and posterior cingulate cortex (PCC). Likewise, patients with first-episode treatment-naive depression had longer ECRT. No significant relation was found between abnormal NH values and the measured clinical variables.Conclusions: Our results suggest patients with first-episode treatment-naive depression have abnormal NH values in the DMN. This highlights the significance of DMN in the pathophysiology of cognitive problems in depression. Our study also found alterations in executive functions in patients with first-episode treatment-naive depression.https://www.frontiersin.org/article/10.3389/fpsyt.2018.00697/fulldepressiondefault mode networknetwork homogeneityattentional network testrest-fMRI |
| spellingShingle | Yujun Gao Menglin Wang RenQiang Yu Yaping Li Ying Yang Xiangxiang Cui Jinou Zheng Abnormal Default Mode Network Homogeneity in Treatment-Naive Patients With First-Episode Depression Frontiers in Psychiatry depression default mode network network homogeneity attentional network test rest-fMRI |
| title | Abnormal Default Mode Network Homogeneity in Treatment-Naive Patients With First-Episode Depression |
| title_full | Abnormal Default Mode Network Homogeneity in Treatment-Naive Patients With First-Episode Depression |
| title_fullStr | Abnormal Default Mode Network Homogeneity in Treatment-Naive Patients With First-Episode Depression |
| title_full_unstemmed | Abnormal Default Mode Network Homogeneity in Treatment-Naive Patients With First-Episode Depression |
| title_short | Abnormal Default Mode Network Homogeneity in Treatment-Naive Patients With First-Episode Depression |
| title_sort | abnormal default mode network homogeneity in treatment naive patients with first episode depression |
| topic | depression default mode network network homogeneity attentional network test rest-fMRI |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00697/full |
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