The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults
Abstract Cardiopulmonary exercise testing (CPET) modalities, treadmill (TM), and cycle ergometer (CE), influence maximal gas exchange and heart rate (HR) responses. Little is known regarding CPET modality effect on submaximal biomarkers during childhood and adolescence. Ninety‐four healthy participa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-07-01
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| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.14178 |
| _version_ | 1818341947530543104 |
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| author | Ronen Bar‐Yoseph Janos Porszasz Shlomit Radom‐Aizik Kim D. Lu Annamarie Stehli Pearl Law Dan M. Cooper |
| author_facet | Ronen Bar‐Yoseph Janos Porszasz Shlomit Radom‐Aizik Kim D. Lu Annamarie Stehli Pearl Law Dan M. Cooper |
| author_sort | Ronen Bar‐Yoseph |
| collection | DOAJ |
| description | Abstract Cardiopulmonary exercise testing (CPET) modalities, treadmill (TM), and cycle ergometer (CE), influence maximal gas exchange and heart rate (HR) responses. Little is known regarding CPET modality effect on submaximal biomarkers during childhood and adolescence. Ninety‐four healthy participants (7–34 y.o., 53% female) performed TM and CE CPET to address two major gaps: (1) the effect of modality on submaximal CPET biomarkers, and (2) estimation of work rate in TM CPET. Breath‐by‐breath gas exchange enabled calculation of linear regression slopes such as V˙O2/ΔHR and ΔV˙E/ΔV˙CO2. Lean body mass (LBM) was measured with dual X‐ray absorptiometry. We tested a novel TM CPET estimate of work rate based on TM velocity2, incline, and body mass (VIM). Like the linear relationship between V˙O2 and work rate in CE CPET, V˙O2 increased linearly with TM VIM. TM ΔV˙O2/ΔHR was highly correlated with CE (r = 0.92), and each increased substantially with LBM (P < 0.0001 for TM and CE). ΔV˙O2/ΔHR was to a small (~8.7%) but significant extent larger in TM (1.6 mL/min/beat, P = 0.04). In contrast, TM and CE ΔV˙E/ΔV˙CO2 decreased significantly with LBM, supporting earlier observations from CE CPET. For both CE and TM, males had significantly higher ΔV˙O2/ΔHR but lower ΔV˙E/ΔV˙CO2 than females. Novel TM CPET biomarkers such as ΔVIM/ΔHR and ∆V˙O2/ΔVIM paralleled effects of LBM observed in CE CPET. TM and CE CPET submaximal biomarkers are not interchangeable, but similarly reflect maturation during critical periods. CPET analysis that utilizes data actually measured (rather than estimated) may improve the clinical value of TM and CE CPET. |
| first_indexed | 2024-12-13T16:06:53Z |
| format | Article |
| id | doaj.art-698a752a787f4641a2752a3f3634c8df |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-13T16:06:53Z |
| publishDate | 2019-07-01 |
| publisher | Wiley |
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| series | Physiological Reports |
| spelling | doaj.art-698a752a787f4641a2752a3f3634c8df2022-12-21T23:39:02ZengWileyPhysiological Reports2051-817X2019-07-01714n/an/a10.14814/phy2.14178The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adultsRonen Bar‐Yoseph0Janos Porszasz1Shlomit Radom‐Aizik2Kim D. Lu3Annamarie Stehli4Pearl Law5Dan M. Cooper6Pediatric Exercise and Genomics Research Center (PERC), Department of Pediatrics University of California Irvine Irvine CaliforniaRehabilitation Clinical Trials Center, Division of Respiratory and Critical Care Physiology and Medicine Los Angeles Biomedical Research Institute at Harbor‐UCLA Medical Center Torrance CaliforniaPediatric Exercise and Genomics Research Center (PERC), Department of Pediatrics University of California Irvine Irvine CaliforniaPediatric Exercise and Genomics Research Center (PERC), Department of Pediatrics University of California Irvine Irvine CaliforniaPediatric Exercise and Genomics Research Center (PERC), Department of Pediatrics University of California Irvine Irvine CaliforniaPediatric Exercise and Genomics Research Center (PERC), Department of Pediatrics University of California Irvine Irvine CaliforniaPediatric Exercise and Genomics Research Center (PERC), Department of Pediatrics University of California Irvine Irvine CaliforniaAbstract Cardiopulmonary exercise testing (CPET) modalities, treadmill (TM), and cycle ergometer (CE), influence maximal gas exchange and heart rate (HR) responses. Little is known regarding CPET modality effect on submaximal biomarkers during childhood and adolescence. Ninety‐four healthy participants (7–34 y.o., 53% female) performed TM and CE CPET to address two major gaps: (1) the effect of modality on submaximal CPET biomarkers, and (2) estimation of work rate in TM CPET. Breath‐by‐breath gas exchange enabled calculation of linear regression slopes such as V˙O2/ΔHR and ΔV˙E/ΔV˙CO2. Lean body mass (LBM) was measured with dual X‐ray absorptiometry. We tested a novel TM CPET estimate of work rate based on TM velocity2, incline, and body mass (VIM). Like the linear relationship between V˙O2 and work rate in CE CPET, V˙O2 increased linearly with TM VIM. TM ΔV˙O2/ΔHR was highly correlated with CE (r = 0.92), and each increased substantially with LBM (P < 0.0001 for TM and CE). ΔV˙O2/ΔHR was to a small (~8.7%) but significant extent larger in TM (1.6 mL/min/beat, P = 0.04). In contrast, TM and CE ΔV˙E/ΔV˙CO2 decreased significantly with LBM, supporting earlier observations from CE CPET. For both CE and TM, males had significantly higher ΔV˙O2/ΔHR but lower ΔV˙E/ΔV˙CO2 than females. Novel TM CPET biomarkers such as ΔVIM/ΔHR and ∆V˙O2/ΔVIM paralleled effects of LBM observed in CE CPET. TM and CE CPET submaximal biomarkers are not interchangeable, but similarly reflect maturation during critical periods. CPET analysis that utilizes data actually measured (rather than estimated) may improve the clinical value of TM and CE CPET.https://doi.org/10.14814/phy2.14178Cycle ergometrypeak oxygen uptake (V˙)pubertysubmaximal biomarkers of fitnesstreadmill |
| spellingShingle | Ronen Bar‐Yoseph Janos Porszasz Shlomit Radom‐Aizik Kim D. Lu Annamarie Stehli Pearl Law Dan M. Cooper The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults Physiological Reports Cycle ergometry peak oxygen uptake (V˙) puberty submaximal biomarkers of fitness treadmill |
| title | The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults |
| title_full | The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults |
| title_fullStr | The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults |
| title_full_unstemmed | The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults |
| title_short | The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults |
| title_sort | effect of test modality on dynamic exercise biomarkers in children adolescents and young adults |
| topic | Cycle ergometry peak oxygen uptake (V˙) puberty submaximal biomarkers of fitness treadmill |
| url | https://doi.org/10.14814/phy2.14178 |
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