Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients
BackgroundGenetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes an...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2018-09-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-364.pdf |
| _version_ | 1828911439273787392 |
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| author | Ji Sun Nam Jung Woo Han Sang Bae Lee Ji Hong You Min Jin Kim Shinae Kang Jong Suk Park Chul Woo Ahn |
| author_facet | Ji Sun Nam Jung Woo Han Sang Bae Lee Ji Hong You Min Jin Kim Shinae Kang Jong Suk Park Chul Woo Ahn |
| author_sort | Ji Sun Nam |
| collection | DOAJ |
| description | BackgroundGenetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients.MethodsOverall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes.ResultsAmong calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion.ConclusionVariations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism. |
| first_indexed | 2024-12-13T19:03:08Z |
| format | Article |
| id | doaj.art-698ae07b3303446c9eca12f07723f0ca |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-13T19:03:08Z |
| publishDate | 2018-09-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-698ae07b3303446c9eca12f07723f0ca2022-12-21T23:34:38ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782018-09-0133336437110.3803/EnM.2018.33.3.364Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes PatientsJi Sun Nam0Jung Woo Han1Sang Bae Lee2Ji Hong You3Min Jin Kim4Shinae Kang5Jong Suk Park6Chul Woo Ahn7Department of Internal Medicine, Yonsei University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, .KoreaDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, .KoreaBackgroundGenetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients.MethodsOverall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes.ResultsAmong calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion.ConclusionVariations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-364.pdfCalpain 10AdiponectinDiabetes mellitus, type 2 |
| spellingShingle | Ji Sun Nam Jung Woo Han Sang Bae Lee Ji Hong You Min Jin Kim Shinae Kang Jong Suk Park Chul Woo Ahn Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients Endocrinology and Metabolism Calpain 10 Adiponectin Diabetes mellitus, type 2 |
| title | Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients |
| title_full | Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients |
| title_fullStr | Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients |
| title_full_unstemmed | Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients |
| title_short | Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients |
| title_sort | calpain 10 and adiponectin gene polymorphisms in korean type 2 diabetes patients |
| topic | Calpain 10 Adiponectin Diabetes mellitus, type 2 |
| url | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-33-364.pdf |
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