Thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a Moroccan hospital
INTRODUCTION: thrombolysis has radically changed the prognosis of acute ischemic stroke. Tenecteplase is a modified form of rt-PA with greater specificity for fibrin and a longer half-life. We report the experience of a Moroccan tertiary hospital in thrombolysis using Tenecteplase. METHODS: we condu...
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| Format: | Article |
| Language: | English |
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The Pan African Medical Journal
2015-05-01
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| Series: | The Pan African Medical Journal |
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https://www.panafrican-med-journal.com/content/article/21/37/pdf/37.pdf
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| author | Ahmed Belkouch Said Jidane Naoufal Chouaib Anass Elbouti Tahir Nebhani Rachid Sirbou Hicham Bakkali Lahcen Belyamani |
| author_facet | Ahmed Belkouch Said Jidane Naoufal Chouaib Anass Elbouti Tahir Nebhani Rachid Sirbou Hicham Bakkali Lahcen Belyamani |
| author_sort | Ahmed Belkouch |
| collection | DOAJ |
| description | INTRODUCTION: thrombolysis has radically changed the prognosis of acute ischemic stroke. Tenecteplase is a modified form of rt-PA with greater specificity for fibrin and a longer half-life. We report the experience of a Moroccan tertiary hospital in thrombolysis using Tenecteplase. METHODS: we conducted an open prospective study of all patients who were treated with Tenecteplase for anacute ischemic stroke admitted to our emergency department. Tenecteplase was administered intravenously at a dose of 0.4 mg/kg single bolus. The primary outcome measure was the proportion of patients achieving significant early neurological recovery defined as an improvement of 4 or more points on the NIHSS score at 24h. RESULTS: 13 patients had been treated by intravenous thrombolysis. 31% were women. Mean age was 63 years old. The mean NIHSS score at admission was 14.3 and 24h after was at 9.1. The right middle cerebral arterywas involved in 69% of cases. The carotid atherosclerosis was predominant 63.3% and the cardio embolic etiology 27%. The mean time to the first medical contact after the onset of symptoms was 3h 30 min. One patient presented a capsulo-lenticular hematoma of 5 mm3 in the same side of the ischemic stroke. CONCLUSION: tenecteplase is a more interesting thrombolytic than alteplase, it seems to be more suitable for thrombolysis in our center. |
| first_indexed | 2024-12-20T16:37:14Z |
| format | Article |
| id | doaj.art-698c0c1cf4c04a84bb383d55097dcd13 |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-20T16:37:14Z |
| publishDate | 2015-05-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-698c0c1cf4c04a84bb383d55097dcd132022-12-21T19:33:08ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882015-05-01213710.11604/pamj.2015.21.37.64916491Thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a Moroccan hospitalAhmed Belkouch0Said Jidane1Naoufal Chouaib2Anass Elbouti3Tahir Nebhani4Rachid Sirbou5Hicham Bakkali6Lahcen Belyamani7 Emergency Department, Mohamed V Military Hospital of Instruction, Faculty of Medicine and Pharmacy, Rabat, Morocco Emergency Department, Mohamed V Military Hospital of Instruction, Faculty of Medicine and Pharmacy, Rabat, Morocco Emergency Department, Mohamed V Military Hospital of Instruction, Faculty of Medicine and Pharmacy, Rabat, Morocco Emergency Department, Mohamed V Military Hospital of Instruction, Faculty of Medicine and Pharmacy, Rabat, Morocco Emergency Department, Mohamed V Military Hospital of Instruction, Faculty of Medicine and Pharmacy, Rabat, Morocco Emergency Department, Mohamed V Military Hospital of Instruction, Faculty of Medicine and Pharmacy, Rabat, Morocco Emergency Department, Mohamed V Military Hospital of Instruction, Faculty of Medicine and Pharmacy, Rabat, Morocco Emergency Department, Mohamed V Military Hospital of Instruction, Faculty of Medicine and Pharmacy, Rabat, Morocco INTRODUCTION: thrombolysis has radically changed the prognosis of acute ischemic stroke. Tenecteplase is a modified form of rt-PA with greater specificity for fibrin and a longer half-life. We report the experience of a Moroccan tertiary hospital in thrombolysis using Tenecteplase. METHODS: we conducted an open prospective study of all patients who were treated with Tenecteplase for anacute ischemic stroke admitted to our emergency department. Tenecteplase was administered intravenously at a dose of 0.4 mg/kg single bolus. The primary outcome measure was the proportion of patients achieving significant early neurological recovery defined as an improvement of 4 or more points on the NIHSS score at 24h. RESULTS: 13 patients had been treated by intravenous thrombolysis. 31% were women. Mean age was 63 years old. The mean NIHSS score at admission was 14.3 and 24h after was at 9.1. The right middle cerebral arterywas involved in 69% of cases. The carotid atherosclerosis was predominant 63.3% and the cardio embolic etiology 27%. The mean time to the first medical contact after the onset of symptoms was 3h 30 min. One patient presented a capsulo-lenticular hematoma of 5 mm3 in the same side of the ischemic stroke. CONCLUSION: tenecteplase is a more interesting thrombolytic than alteplase, it seems to be more suitable for thrombolysis in our center. https://www.panafrican-med-journal.com/content/article/21/37/pdf/37.pdf acute ischemic strokethrombolysistenecteplase |
| spellingShingle | Ahmed Belkouch Said Jidane Naoufal Chouaib Anass Elbouti Tahir Nebhani Rachid Sirbou Hicham Bakkali Lahcen Belyamani Thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a Moroccan hospital The Pan African Medical Journal acute ischemic stroke thrombolysis tenecteplase |
| title | Thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a Moroccan hospital |
| title_full | Thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a Moroccan hospital |
| title_fullStr | Thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a Moroccan hospital |
| title_full_unstemmed | Thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a Moroccan hospital |
| title_short | Thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a Moroccan hospital |
| title_sort | thrombolysis for acute ischemic stroke by tenecteplase in the emergency department of a moroccan hospital |
| topic | acute ischemic stroke thrombolysis tenecteplase |
| url |
https://www.panafrican-med-journal.com/content/article/21/37/pdf/37.pdf
|
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