Comparison of integrated PET/MRI with PET/CT in evaluation of endometrial cancer: a retrospective analysis of 81 cases
Background The objective of this study was to compare the diagnostic value of integrated PET/MRI with PET/CT for assessment of regional lymph node metastasis and deep myometrial invasion detection of endometrial cancer. Methods Eighty-one patients with biopsy-proven endometrial cancer underwent preo...
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PeerJ Inc.
2019-07-01
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| author | Li-hua Bian Min Wang Jing Gong Hong-hong Liu Nan Wang Na Wen Wen-sheng Fan Bai-xuan Xu Ming-yang Wang Ming-xia Ye Yuan-guang Meng |
| author_facet | Li-hua Bian Min Wang Jing Gong Hong-hong Liu Nan Wang Na Wen Wen-sheng Fan Bai-xuan Xu Ming-yang Wang Ming-xia Ye Yuan-guang Meng |
| author_sort | Li-hua Bian |
| collection | DOAJ |
| description | Background The objective of this study was to compare the diagnostic value of integrated PET/MRI with PET/CT for assessment of regional lymph node metastasis and deep myometrial invasion detection of endometrial cancer. Methods Eighty-one patients with biopsy-proven endometrial cancer underwent preoperative PET/CT (n = 37) and integrated PET/MRI (n = 44) for initial staging. The diagnostic performance of PET/CT and integrated PET/MRI for assessing the extent of the primary tumor and metastasis to the regional lymph nodes was evaluated by two experienced readers. Histopathological and follow-up imaging results were used as the gold standard. McNemar’s test was employed for statistical analysis. Results Integrated PET/MRI and PET/CT both detected 100% of the primary tumors. Integrated PET/MRI proved significantly more sensitivity and specificity than PET/CT in regional lymph node metastasis detection (P = 0.015 and P < 0.001, respectively). The overall accuracy of myometrial invasion detection for PET/CT and Integrated PET/MRI was 45.9% and 81.8%, respectively. Integrated PET/MRI proved significantly more accurate than PET/CT (P < 0.001). Conclusion Integrated PET/MRI, which complements the individual advantages of MRI and PET, is a valuable technique for the assessment of the lymph node metastasis and myometrial invasion in patients with endometrial cancer. |
| first_indexed | 2024-03-09T07:27:12Z |
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| id | doaj.art-698d46c93ce74361868201ca4bffa630 |
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| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:27:12Z |
| publishDate | 2019-07-01 |
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| spelling | doaj.art-698d46c93ce74361868201ca4bffa6302023-12-03T06:52:21ZengPeerJ Inc.PeerJ2167-83592019-07-017e708110.7717/peerj.7081Comparison of integrated PET/MRI with PET/CT in evaluation of endometrial cancer: a retrospective analysis of 81 casesLi-hua BianMin WangJing GongHong-hong LiuNan WangNa WenWen-sheng FanBai-xuan XuMing-yang WangMing-xia YeYuan-guang MengBackground The objective of this study was to compare the diagnostic value of integrated PET/MRI with PET/CT for assessment of regional lymph node metastasis and deep myometrial invasion detection of endometrial cancer. Methods Eighty-one patients with biopsy-proven endometrial cancer underwent preoperative PET/CT (n = 37) and integrated PET/MRI (n = 44) for initial staging. The diagnostic performance of PET/CT and integrated PET/MRI for assessing the extent of the primary tumor and metastasis to the regional lymph nodes was evaluated by two experienced readers. Histopathological and follow-up imaging results were used as the gold standard. McNemar’s test was employed for statistical analysis. Results Integrated PET/MRI and PET/CT both detected 100% of the primary tumors. Integrated PET/MRI proved significantly more sensitivity and specificity than PET/CT in regional lymph node metastasis detection (P = 0.015 and P < 0.001, respectively). The overall accuracy of myometrial invasion detection for PET/CT and Integrated PET/MRI was 45.9% and 81.8%, respectively. Integrated PET/MRI proved significantly more accurate than PET/CT (P < 0.001). Conclusion Integrated PET/MRI, which complements the individual advantages of MRI and PET, is a valuable technique for the assessment of the lymph node metastasis and myometrial invasion in patients with endometrial cancer.https://peerj.com/articles/7081.pdfEndometrial cancerStagingPET/CTIntegrated PET/MRI |
| spellingShingle | Li-hua Bian Min Wang Jing Gong Hong-hong Liu Nan Wang Na Wen Wen-sheng Fan Bai-xuan Xu Ming-yang Wang Ming-xia Ye Yuan-guang Meng Comparison of integrated PET/MRI with PET/CT in evaluation of endometrial cancer: a retrospective analysis of 81 cases PeerJ Endometrial cancer Staging PET/CT Integrated PET/MRI |
| title | Comparison of integrated PET/MRI with PET/CT in evaluation of endometrial cancer: a retrospective analysis of 81 cases |
| title_full | Comparison of integrated PET/MRI with PET/CT in evaluation of endometrial cancer: a retrospective analysis of 81 cases |
| title_fullStr | Comparison of integrated PET/MRI with PET/CT in evaluation of endometrial cancer: a retrospective analysis of 81 cases |
| title_full_unstemmed | Comparison of integrated PET/MRI with PET/CT in evaluation of endometrial cancer: a retrospective analysis of 81 cases |
| title_short | Comparison of integrated PET/MRI with PET/CT in evaluation of endometrial cancer: a retrospective analysis of 81 cases |
| title_sort | comparison of integrated pet mri with pet ct in evaluation of endometrial cancer a retrospective analysis of 81 cases |
| topic | Endometrial cancer Staging PET/CT Integrated PET/MRI |
| url | https://peerj.com/articles/7081.pdf |
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