A randomized clinical trial examining the impact of LGG probiotic supplementation on psychological status in middle-aged and older adults
Cognitive decline is common in older adults and more than 5 million Americans suffer from Alzheimer's disease (AD). A number of physiological processes including systemic inflammation, excess adiposity, and impaired glucoregulation arise from a combination of genetic and behavioral factors and...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-12-01
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| Series: | Contemporary Clinical Trials Communications |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865418300863 |
| _version_ | 1818910912121143296 |
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| author | Victoria Sanborn M. Andrea Azcarate-Peril John Updegraff Lisa M. Manderino John Gunstad |
| author_facet | Victoria Sanborn M. Andrea Azcarate-Peril John Updegraff Lisa M. Manderino John Gunstad |
| author_sort | Victoria Sanborn |
| collection | DOAJ |
| description | Cognitive decline is common in older adults and more than 5 million Americans suffer from Alzheimer's disease (AD). A number of physiological processes including systemic inflammation, excess adiposity, and impaired glucoregulation arise from a combination of genetic and behavioral factors and increase risk for developing AD or other forms of dementia. Recent research suggests that the gut microbiome may moderate these pathological processes and possibly influence cognitive outcomes. This paper reviews the methodology for a double-blind, randomized clinical trial examining the influence of Lactobacillus GG (LGG) probiotic supplementation on mood and cognitive functioning in middle-aged and older adults. Our two primary hypotheses include: 1) Participants randomized to the probiotic group will show greater improvements in psychological status compared to participants in the placebo group; 2) Participants randomized to the probiotic group will show greater improvements in executive functioning and processing speed, as evidenced through performance on neuropsychological testing, than participants in the placebo group. We anticipate these results will inform future efforts on the feasibility of LGG probiotic supplementation as an intervention for psychological status and cognitive functioning and further elucidate the link between the gut microbiome and cognitive health. Keywords: Probiotics, Lactobacillus rhamnosus, Cognitive function, Executive function, Alzheimer's disease, Depression |
| first_indexed | 2024-12-19T22:50:20Z |
| format | Article |
| id | doaj.art-698e2fbc174c4e56a4d6a79d20e18028 |
| institution | Directory Open Access Journal |
| issn | 2451-8654 |
| language | English |
| last_indexed | 2024-12-19T22:50:20Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Contemporary Clinical Trials Communications |
| spelling | doaj.art-698e2fbc174c4e56a4d6a79d20e180282022-12-21T20:02:49ZengElsevierContemporary Clinical Trials Communications2451-86542018-12-0112192197A randomized clinical trial examining the impact of LGG probiotic supplementation on psychological status in middle-aged and older adultsVictoria Sanborn0M. Andrea Azcarate-Peril1John Updegraff2Lisa M. Manderino3John Gunstad4Department of Psychological Sciences, Kent State University, USA; Corresponding author. 144 Kent Hall, Kent State University, Kent, OH, 44242, USA.Department of Cell Biology and Physiology and Microbiome Core Facility, UNC School of Medicine, USADepartment of Psychological Sciences, Kent State University, USADepartment of Psychological Sciences, Kent State University, USADepartment of Psychological Sciences, Kent State University, USACognitive decline is common in older adults and more than 5 million Americans suffer from Alzheimer's disease (AD). A number of physiological processes including systemic inflammation, excess adiposity, and impaired glucoregulation arise from a combination of genetic and behavioral factors and increase risk for developing AD or other forms of dementia. Recent research suggests that the gut microbiome may moderate these pathological processes and possibly influence cognitive outcomes. This paper reviews the methodology for a double-blind, randomized clinical trial examining the influence of Lactobacillus GG (LGG) probiotic supplementation on mood and cognitive functioning in middle-aged and older adults. Our two primary hypotheses include: 1) Participants randomized to the probiotic group will show greater improvements in psychological status compared to participants in the placebo group; 2) Participants randomized to the probiotic group will show greater improvements in executive functioning and processing speed, as evidenced through performance on neuropsychological testing, than participants in the placebo group. We anticipate these results will inform future efforts on the feasibility of LGG probiotic supplementation as an intervention for psychological status and cognitive functioning and further elucidate the link between the gut microbiome and cognitive health. Keywords: Probiotics, Lactobacillus rhamnosus, Cognitive function, Executive function, Alzheimer's disease, Depressionhttp://www.sciencedirect.com/science/article/pii/S2451865418300863 |
| spellingShingle | Victoria Sanborn M. Andrea Azcarate-Peril John Updegraff Lisa M. Manderino John Gunstad A randomized clinical trial examining the impact of LGG probiotic supplementation on psychological status in middle-aged and older adults Contemporary Clinical Trials Communications |
| title | A randomized clinical trial examining the impact of LGG probiotic supplementation on psychological status in middle-aged and older adults |
| title_full | A randomized clinical trial examining the impact of LGG probiotic supplementation on psychological status in middle-aged and older adults |
| title_fullStr | A randomized clinical trial examining the impact of LGG probiotic supplementation on psychological status in middle-aged and older adults |
| title_full_unstemmed | A randomized clinical trial examining the impact of LGG probiotic supplementation on psychological status in middle-aged and older adults |
| title_short | A randomized clinical trial examining the impact of LGG probiotic supplementation on psychological status in middle-aged and older adults |
| title_sort | randomized clinical trial examining the impact of lgg probiotic supplementation on psychological status in middle aged and older adults |
| url | http://www.sciencedirect.com/science/article/pii/S2451865418300863 |
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