Colonic PDGFRα Overexpression Accompanied Forkhead Transcription Factor FOXO3 Up-Regulation in STZ-Induced Diabetic Mice

Colonic PDGFRα Overexpression Accompanied Forkhead Transcription Factor FOXO3 Up-Regulation in STZ-Induced Diabetic Mice

Background: Colonic transit disorder-induced constipation is a major complication in diabetic patients. PDGFRα+ (platelet-derived growth factor receptor α-positive) cells play critical roles in the inhibitory regulation of colonic motility, and FOXO3 (forkhead transcription factor 3) has a broad ran...

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Bibliographic Details
Main Authors: Hongli Lu, Chunmei Zhang, Nina Song, Chen Lu, Ling Tong, Xu Huang, Young-chul Kim, Jie Chen, Wenxie Xu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
PDGFRα
Diabetes mellitus
FOXO3
Colonic dysmotility
Online Access:http://www.karger.com/Article/FullText/480335

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