The Global, Regional, and National Uterine Cancer Burden Attributable to High BMI from 1990 to 2019: A Systematic Analysis of the Global Burden of Disease Study 2019
Uterine cancer (UC) is the most common gynecologic malignancy, and high body mass index (BMI) is a poor prognostic factor for UC. However, the associated burden has not been fully assessed, which is crucial for women’s health management and the prevention and control of UC. Therefore, we utilized th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/5/1874 |
| _version_ | 1797615023119400960 |
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| author | Jingchun Liu Haoyu Wang Zhi Wang Wuyue Han Li Hong |
| author_facet | Jingchun Liu Haoyu Wang Zhi Wang Wuyue Han Li Hong |
| author_sort | Jingchun Liu |
| collection | DOAJ |
| description | Uterine cancer (UC) is the most common gynecologic malignancy, and high body mass index (BMI) is a poor prognostic factor for UC. However, the associated burden has not been fully assessed, which is crucial for women’s health management and the prevention and control of UC. Therefore, we utilized the Global Burden of Disease Study (GBD) 2019 to describe the global, regional, and national UC burden due to high BMI from 1990 to 2019. The data show that globally, women’s high BMI exposure is increasing annually, with most regions having higher rates of high BMI exposure than the global average. In 2019, 36,486 [95% uncertainty interval (UI): 25,131 to 49,165] UC deaths were attributed to high BMI globally, accounting for 39.81% (95% UI: 27.64 to 52.67) of all UC deaths. The age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years (DALY) rate (ASDR) for high BMI-associated UC remained stable globally from 1990 to 2019, with significant differences across regions. Higher ASDR and ASMR were found in higher socio-demographic index (SDI) regions, and lower SDI regions had the fastest estimated annual percentage changes (EAPCs) for both rates. Among all age groups, the fatal outcome of UC with high BMI occurs most frequently in women over 80 years old. |
| first_indexed | 2024-03-11T07:20:36Z |
| format | Article |
| id | doaj.art-69903c4f1099420ab72bf9cb4f476f92 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T07:20:36Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-69903c4f1099420ab72bf9cb4f476f922023-11-17T07:59:31ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01125187410.3390/jcm12051874The Global, Regional, and National Uterine Cancer Burden Attributable to High BMI from 1990 to 2019: A Systematic Analysis of the Global Burden of Disease Study 2019Jingchun Liu0Haoyu Wang1Zhi Wang2Wuyue Han3Li Hong4Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan 430064, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan 430064, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan 430064, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan 430064, ChinaDepartment of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan 430064, ChinaUterine cancer (UC) is the most common gynecologic malignancy, and high body mass index (BMI) is a poor prognostic factor for UC. However, the associated burden has not been fully assessed, which is crucial for women’s health management and the prevention and control of UC. Therefore, we utilized the Global Burden of Disease Study (GBD) 2019 to describe the global, regional, and national UC burden due to high BMI from 1990 to 2019. The data show that globally, women’s high BMI exposure is increasing annually, with most regions having higher rates of high BMI exposure than the global average. In 2019, 36,486 [95% uncertainty interval (UI): 25,131 to 49,165] UC deaths were attributed to high BMI globally, accounting for 39.81% (95% UI: 27.64 to 52.67) of all UC deaths. The age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years (DALY) rate (ASDR) for high BMI-associated UC remained stable globally from 1990 to 2019, with significant differences across regions. Higher ASDR and ASMR were found in higher socio-demographic index (SDI) regions, and lower SDI regions had the fastest estimated annual percentage changes (EAPCs) for both rates. Among all age groups, the fatal outcome of UC with high BMI occurs most frequently in women over 80 years old.https://www.mdpi.com/2077-0383/12/5/1874uterine cancerhigh BMIdeathdisability-adjusted life yearglobal burden of disease |
| spellingShingle | Jingchun Liu Haoyu Wang Zhi Wang Wuyue Han Li Hong The Global, Regional, and National Uterine Cancer Burden Attributable to High BMI from 1990 to 2019: A Systematic Analysis of the Global Burden of Disease Study 2019 Journal of Clinical Medicine uterine cancer high BMI death disability-adjusted life year global burden of disease |
| title | The Global, Regional, and National Uterine Cancer Burden Attributable to High BMI from 1990 to 2019: A Systematic Analysis of the Global Burden of Disease Study 2019 |
| title_full | The Global, Regional, and National Uterine Cancer Burden Attributable to High BMI from 1990 to 2019: A Systematic Analysis of the Global Burden of Disease Study 2019 |
| title_fullStr | The Global, Regional, and National Uterine Cancer Burden Attributable to High BMI from 1990 to 2019: A Systematic Analysis of the Global Burden of Disease Study 2019 |
| title_full_unstemmed | The Global, Regional, and National Uterine Cancer Burden Attributable to High BMI from 1990 to 2019: A Systematic Analysis of the Global Burden of Disease Study 2019 |
| title_short | The Global, Regional, and National Uterine Cancer Burden Attributable to High BMI from 1990 to 2019: A Systematic Analysis of the Global Burden of Disease Study 2019 |
| title_sort | global regional and national uterine cancer burden attributable to high bmi from 1990 to 2019 a systematic analysis of the global burden of disease study 2019 |
| topic | uterine cancer high BMI death disability-adjusted life year global burden of disease |
| url | https://www.mdpi.com/2077-0383/12/5/1874 |
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