Curcumin piperidone derivatives induce caspase-dependent apoptosis and suppress miRNA-21 expression in LN-18 human glioblastoma cells

Curcumin piperidone derivatives induce caspase-dependent apoptosis and suppress miRNA-21 expression in LN-18 human glioblastoma cells

Abstract Background Previously, we have reported on the two curcuminoid analogues with piperidone derivatives, namely FLDP-5 and FLDP-8 have more potent anti-proliferative and anti-migration effects than curcumin. In this study, we further investigated the mode of cell death and the mechanism involv...

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Bibliographic Details
Main Authors: Nur Syahirah Che Razali, Kok Wai Lam, Nor Fadilah Rajab, A. Rahman A. Jamal, Nurul Farahana Kamaludin, Kok Meng Chan
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Genes and Environment
Subjects:
Glioblastoma
Curcuminoid analogue
Curcumin
Apoptosis
Caspase
MiRNA-21
Online Access:https://doi.org/10.1186/s41021-023-00297-y

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