Dietary Habits and Nutrient Deficiencies in a Cohort of European Crohn’s Disease Adult Patients
Wrong dietary habits, such as the Western-style diet, are considered important risk factors for the development of Inflammatory Bowel Diseases (IBDs). Nevertheless, the role of dietary patterns in the clinical management of IBD patients has not been fully investigated yet. Fifty-four patients diagno...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/2/1494 |
| _version_ | 1797441214893522944 |
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| author | Fernando Rizzello Paolo Gionchetti Enzo Spisni Ilaria Maria Saracino Irene Bellocchio Renato Spigarelli Noemi Collini Veronica Imbesi Thierry Dervieux Patrizia Alvisi Maria Chiara Valerii |
| author_facet | Fernando Rizzello Paolo Gionchetti Enzo Spisni Ilaria Maria Saracino Irene Bellocchio Renato Spigarelli Noemi Collini Veronica Imbesi Thierry Dervieux Patrizia Alvisi Maria Chiara Valerii |
| author_sort | Fernando Rizzello |
| collection | DOAJ |
| description | Wrong dietary habits, such as the Western-style diet, are considered important risk factors for the development of Inflammatory Bowel Diseases (IBDs). Nevertheless, the role of dietary patterns in the clinical management of IBD patients has not been fully investigated yet. Fifty-four patients diagnosed with active Crohn’s disease (CD) were enrolled and subjected to nutritional intake analysis through a weekly food diary. Nutritional patterns were analyzed, and nutrient intake was compared with those of 30 healthy subjects (HS). Blood levels of cholesterol, folic acid, minerals (K, Mg, Fe) and amino acids, were measured in CD patients to assess the presence of nutritional deficiencies. CD patients, with respect to HS, consumed significantly lower amounts of fiber, vitamins (A, E, C, B6, folic acid) and β-carotene. Their calcium, potassium, phosphorus, iron, magnesium, copper and iodine intake were also found to be significantly lower. In blood, CD patients had significantly lower concentrations of total cholesterol, potassium, iron, and amino acids. Active CD patient diet was significantly different from those of HS and may contribute to the establishment of nutritional deficiencies. Intestinal malabsorption was evidenced in these patients. Correction of the diet with specific nutritional plans is a necessary therapeutic step for these patients. ClinicalTrials.gov: NCT02580864. |
| first_indexed | 2024-03-09T12:20:50Z |
| format | Article |
| id | doaj.art-6991b3fc3d8b41c4bb0fca4d30f13e5a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:20:50Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6991b3fc3d8b41c4bb0fca4d30f13e5a2023-11-30T22:41:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01242149410.3390/ijms24021494Dietary Habits and Nutrient Deficiencies in a Cohort of European Crohn’s Disease Adult PatientsFernando Rizzello0Paolo Gionchetti1Enzo Spisni2Ilaria Maria Saracino3Irene Bellocchio4Renato Spigarelli5Noemi Collini6Veronica Imbesi7Thierry Dervieux8Patrizia Alvisi9Maria Chiara Valerii10IBD Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyIBD Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Bologna, Via Selmi 3, 40126 Bologna, ItalyMicrobiology Unit, Department of Specialized, Experimental and Diagnostic Medicine, St. Orsola Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Bologna, Via Selmi 3, 40126 Bologna, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Bologna, Via Selmi 3, 40126 Bologna, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Bologna, Via Selmi 3, 40126 Bologna, ItalyIBD Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyPrometheus Laboratories, 9410 Carroll Park Dr., San Diego, CA 92121, USAPediatric Gastroenterology Unit, Maggiore Hospital, Largo Nigrisoli, 2, 40133 Bologna, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Bologna, Via Selmi 3, 40126 Bologna, ItalyWrong dietary habits, such as the Western-style diet, are considered important risk factors for the development of Inflammatory Bowel Diseases (IBDs). Nevertheless, the role of dietary patterns in the clinical management of IBD patients has not been fully investigated yet. Fifty-four patients diagnosed with active Crohn’s disease (CD) were enrolled and subjected to nutritional intake analysis through a weekly food diary. Nutritional patterns were analyzed, and nutrient intake was compared with those of 30 healthy subjects (HS). Blood levels of cholesterol, folic acid, minerals (K, Mg, Fe) and amino acids, were measured in CD patients to assess the presence of nutritional deficiencies. CD patients, with respect to HS, consumed significantly lower amounts of fiber, vitamins (A, E, C, B6, folic acid) and β-carotene. Their calcium, potassium, phosphorus, iron, magnesium, copper and iodine intake were also found to be significantly lower. In blood, CD patients had significantly lower concentrations of total cholesterol, potassium, iron, and amino acids. Active CD patient diet was significantly different from those of HS and may contribute to the establishment of nutritional deficiencies. Intestinal malabsorption was evidenced in these patients. Correction of the diet with specific nutritional plans is a necessary therapeutic step for these patients. ClinicalTrials.gov: NCT02580864.https://www.mdpi.com/1422-0067/24/2/1494Crohn’s diseasevitaminsmineralnutrient deficiencyintestinal malabsorption |
| spellingShingle | Fernando Rizzello Paolo Gionchetti Enzo Spisni Ilaria Maria Saracino Irene Bellocchio Renato Spigarelli Noemi Collini Veronica Imbesi Thierry Dervieux Patrizia Alvisi Maria Chiara Valerii Dietary Habits and Nutrient Deficiencies in a Cohort of European Crohn’s Disease Adult Patients International Journal of Molecular Sciences Crohn’s disease vitamins mineral nutrient deficiency intestinal malabsorption |
| title | Dietary Habits and Nutrient Deficiencies in a Cohort of European Crohn’s Disease Adult Patients |
| title_full | Dietary Habits and Nutrient Deficiencies in a Cohort of European Crohn’s Disease Adult Patients |
| title_fullStr | Dietary Habits and Nutrient Deficiencies in a Cohort of European Crohn’s Disease Adult Patients |
| title_full_unstemmed | Dietary Habits and Nutrient Deficiencies in a Cohort of European Crohn’s Disease Adult Patients |
| title_short | Dietary Habits and Nutrient Deficiencies in a Cohort of European Crohn’s Disease Adult Patients |
| title_sort | dietary habits and nutrient deficiencies in a cohort of european crohn s disease adult patients |
| topic | Crohn’s disease vitamins mineral nutrient deficiency intestinal malabsorption |
| url | https://www.mdpi.com/1422-0067/24/2/1494 |
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