Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma
Tyrosine is an essential ketogenic and glycogenic amino acid for the human body, which means that tyrosine is not only involved in protein metabolism, but also participates in the metabolism of lipids and carbohydrates. The liver is an important place for metabolism of lipids, carbohydrates, and pro...
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MDPI AG
2022-01-01
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| author | Jiyan Wang Yaya Qiao Huanran Sun Hongkai Chang Huifang Zhao Shuai Zhang Changliang Shan |
| author_facet | Jiyan Wang Yaya Qiao Huanran Sun Hongkai Chang Huifang Zhao Shuai Zhang Changliang Shan |
| author_sort | Jiyan Wang |
| collection | DOAJ |
| description | Tyrosine is an essential ketogenic and glycogenic amino acid for the human body, which means that tyrosine is not only involved in protein metabolism, but also participates in the metabolism of lipids and carbohydrates. The liver is an important place for metabolism of lipids, carbohydrates, and proteins. The metabolic process of biological macro-molecules is a basis for maintaining the physiological activities of organisms, but the cross-linking mechanism of these processes is still unclear. Here, we found that the tyrosine-metabolizing enzymes, which were specifically and highly expressed in the liver, were significantly down-regulated in hepatocellular carcinoma (HCC), and had a correlation with a poor prognosis of HCC patients. Further analysis found that the reduction of tyrosine metabolism would activate the cell cycle and promote cell proliferation. In addition, we also found that the solute carrier family 27 member 5 (SLC27A5) regulates the expression of tyrosine-metabolizing enzymes through nuclear factor erythroid 2-related factor 2 (NRF2). Therefore, the SLC27A5 and tyrosine-metabolizing enzymes that we have identified coordinate lipid and tyrosine metabolism, regulate the cell cycle, and are potential targets for cancer treatment. |
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| language | English |
| last_indexed | 2024-03-09T22:33:50Z |
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| spelling | doaj.art-69931adfc06c4581a83c9c5070e0ba6e2023-11-23T18:52:25ZengMDPI AGBiomedicines2227-90592022-01-0110223410.3390/biomedicines10020234Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular CarcinomaJiyan Wang0Yaya Qiao1Huanran Sun2Hongkai Chang3Huifang Zhao4Shuai Zhang5Changliang Shan6State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaTyrosine is an essential ketogenic and glycogenic amino acid for the human body, which means that tyrosine is not only involved in protein metabolism, but also participates in the metabolism of lipids and carbohydrates. The liver is an important place for metabolism of lipids, carbohydrates, and proteins. The metabolic process of biological macro-molecules is a basis for maintaining the physiological activities of organisms, but the cross-linking mechanism of these processes is still unclear. Here, we found that the tyrosine-metabolizing enzymes, which were specifically and highly expressed in the liver, were significantly down-regulated in hepatocellular carcinoma (HCC), and had a correlation with a poor prognosis of HCC patients. Further analysis found that the reduction of tyrosine metabolism would activate the cell cycle and promote cell proliferation. In addition, we also found that the solute carrier family 27 member 5 (SLC27A5) regulates the expression of tyrosine-metabolizing enzymes through nuclear factor erythroid 2-related factor 2 (NRF2). Therefore, the SLC27A5 and tyrosine-metabolizing enzymes that we have identified coordinate lipid and tyrosine metabolism, regulate the cell cycle, and are potential targets for cancer treatment.https://www.mdpi.com/2227-9059/10/2/234hepatocellular carcinomasolute carrier family 27 member 5 (SLC27A5)tyrosine metabolismlipids synthesiscell cycle |
| spellingShingle | Jiyan Wang Yaya Qiao Huanran Sun Hongkai Chang Huifang Zhao Shuai Zhang Changliang Shan Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma Biomedicines hepatocellular carcinoma solute carrier family 27 member 5 (SLC27A5) tyrosine metabolism lipids synthesis cell cycle |
| title | Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma |
| title_full | Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma |
| title_fullStr | Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma |
| title_full_unstemmed | Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma |
| title_short | Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma |
| title_sort | decreased slc27a5 suppresses lipid synthesis and tyrosine metabolism to activate the cell cycle in hepatocellular carcinoma |
| topic | hepatocellular carcinoma solute carrier family 27 member 5 (SLC27A5) tyrosine metabolism lipids synthesis cell cycle |
| url | https://www.mdpi.com/2227-9059/10/2/234 |
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