Mapping the structural core of human cerebral cortex.
Structurally segregated and functionally specialized regions of the human cerebral cortex are interconnected by a dense network of cortico-cortical axonal pathways. By using diffusion spectrum imaging, we noninvasively mapped these pathways within and across cortical hemispheres in individual human...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-07-01
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| Series: | PLoS Biology |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18597554/?tool=EBI |
| _version_ | 1797848176103784448 |
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| author | Patric Hagmann Leila Cammoun Xavier Gigandet Reto Meuli Christopher J Honey Van J Wedeen Olaf Sporns |
| author_facet | Patric Hagmann Leila Cammoun Xavier Gigandet Reto Meuli Christopher J Honey Van J Wedeen Olaf Sporns |
| author_sort | Patric Hagmann |
| collection | DOAJ |
| description | Structurally segregated and functionally specialized regions of the human cerebral cortex are interconnected by a dense network of cortico-cortical axonal pathways. By using diffusion spectrum imaging, we noninvasively mapped these pathways within and across cortical hemispheres in individual human participants. An analysis of the resulting large-scale structural brain networks reveals a structural core within posterior medial and parietal cerebral cortex, as well as several distinct temporal and frontal modules. Brain regions within the structural core share high degree, strength, and betweenness centrality, and they constitute connector hubs that link all major structural modules. The structural core contains brain regions that form the posterior components of the human default network. Looking both within and outside of core regions, we observed a substantial correspondence between structural connectivity and resting-state functional connectivity measured in the same participants. The spatial and topological centrality of the core within cortex suggests an important role in functional integration. |
| first_indexed | 2024-04-09T18:24:19Z |
| format | Article |
| id | doaj.art-699440b8924f48e984214a6abf9d462a |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-04-09T18:24:19Z |
| publishDate | 2008-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-699440b8924f48e984214a6abf9d462a2023-04-12T05:30:45ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852008-07-0167e15910.1371/journal.pbio.0060159Mapping the structural core of human cerebral cortex.Patric HagmannLeila CammounXavier GigandetReto MeuliChristopher J HoneyVan J WedeenOlaf SpornsStructurally segregated and functionally specialized regions of the human cerebral cortex are interconnected by a dense network of cortico-cortical axonal pathways. By using diffusion spectrum imaging, we noninvasively mapped these pathways within and across cortical hemispheres in individual human participants. An analysis of the resulting large-scale structural brain networks reveals a structural core within posterior medial and parietal cerebral cortex, as well as several distinct temporal and frontal modules. Brain regions within the structural core share high degree, strength, and betweenness centrality, and they constitute connector hubs that link all major structural modules. The structural core contains brain regions that form the posterior components of the human default network. Looking both within and outside of core regions, we observed a substantial correspondence between structural connectivity and resting-state functional connectivity measured in the same participants. The spatial and topological centrality of the core within cortex suggests an important role in functional integration.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18597554/?tool=EBI |
| spellingShingle | Patric Hagmann Leila Cammoun Xavier Gigandet Reto Meuli Christopher J Honey Van J Wedeen Olaf Sporns Mapping the structural core of human cerebral cortex. PLoS Biology |
| title | Mapping the structural core of human cerebral cortex. |
| title_full | Mapping the structural core of human cerebral cortex. |
| title_fullStr | Mapping the structural core of human cerebral cortex. |
| title_full_unstemmed | Mapping the structural core of human cerebral cortex. |
| title_short | Mapping the structural core of human cerebral cortex. |
| title_sort | mapping the structural core of human cerebral cortex |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18597554/?tool=EBI |
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